Synthesis and biological evaluation of decursin, prantschimgin and their derivatives

Yan Xia; Kyung Hoon Min; Kyeong Lee

doi:10.5012/bkcs.2009.30.1.043

Synthesis and biological evaluation of decursin, prantschimgin and their derivatives

Yan Xia
, Kyung Hoon Min
, Kyeong Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

Original language	English
Pages (from-to)	43-48
Number of pages	6
Journal	Bulletin of the Korean Chemical Society
Volume	30
Issue number	1
DOIs	https://doi.org/10.5012/bkcs.2009.30.1.043
State	Published - Jan 2009

Keywords

Coumarins
Decursin
Multidrug resistance
P-glycoprotein
Prantschimgin

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10.5012/bkcs.2009.30.1.043

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title = "Synthesis and biological evaluation of decursin, prantschimgin and their derivatives",

abstract = "The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.",

keywords = "Coumarins, Decursin, Multidrug resistance, P-glycoprotein, Prantschimgin",

author = "Yan Xia and Min, \{Kyung Hoon\} and Kyeong Lee",

year = "2009",

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AU - Xia, Yan

AU - Min, Kyung Hoon

AU - Lee, Kyeong

PY - 2009/1

Y1 - 2009/1

N2 - The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

AB - The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

KW - Coumarins

KW - Decursin

KW - Multidrug resistance

KW - P-glycoprotein

KW - Prantschimgin

UR - https://www.scopus.com/pages/publications/60149107989

U2 - 10.5012/bkcs.2009.30.1.043

DO - 10.5012/bkcs.2009.30.1.043

M3 - Article

AN - SCOPUS:60149107989

SN - 0253-2964

VL - 30

SP - 43

EP - 48

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

IS - 1

ER -

Synthesis and biological evaluation of decursin, prantschimgin and their derivatives

Abstract

Keywords

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