Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Lak Shin Jeong; Hyung Ryong Moon; Jae Gyu Park; Dae Hong Shin; Won Jun Choi; Kang Man Lee; Hea Ok Kim; Moon Woo Chun; Hee Doo Kim; Joong Hyup Kim

doi:10.1081/NCN-120021961

Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Lak Shin Jeong, Hyung Ryong Moon, Jae Gyu Park, Dae Hong Shin, Won Jun Choi, Kang Man Lee, Hea Ok Kim, Moon Woo Chun, Hee Doo Kim, Joong Hyup Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

Original language	English
Pages (from-to)	589-592
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	22
Issue number	5-8
DOIs	https://doi.org/10.1081/NCN-120021961
State	Published - 2003

Keywords

Halo-neplanocin A
Mechanism-based inhibitor
S-Adenosylhomocysteine hydrolase

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10.1081/NCN-120021961

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title = "Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase",

abstract = "Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.",

keywords = "Halo-neplanocin A, Mechanism-based inhibitor, S-Adenosylhomocysteine hydrolase",

author = "Jeong, {Lak Shin} and Moon, {Hyung Ryong} and Park, {Jae Gyu} and Shin, {Dae Hong} and Choi, {Won Jun} and Lee, {Kang Man} and Kim, {Hea Ok} and Chun, {Moon Woo} and Kim, {Hee Doo} and Kim, {Joong Hyup}",

year = "2003",

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volume = "22",

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T1 - Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

AU - Jeong, Lak Shin

AU - Moon, Hyung Ryong

AU - Park, Jae Gyu

AU - Shin, Dae Hong

AU - Choi, Won Jun

AU - Lee, Kang Man

AU - Kim, Hea Ok

AU - Chun, Moon Woo

AU - Kim, Hee Doo

AU - Kim, Joong Hyup

PY - 2003

Y1 - 2003

N2 - Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

AB - Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

KW - Halo-neplanocin A

KW - Mechanism-based inhibitor

KW - S-Adenosylhomocysteine hydrolase

UR - http://www.scopus.com/inward/record.url?scp=0141425747&partnerID=8YFLogxK

U2 - 10.1081/NCN-120021961

DO - 10.1081/NCN-120021961

M3 - Article

C2 - 14565234

AN - SCOPUS:0141425747

SN - 1525-7770

VL - 22

SP - 589

EP - 592

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-8

ER -

Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

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Keywords

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