Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

  • Lak Shin Jeong
  • , Hyung Ryong Moon
  • , Jae Gyu Park
  • , Dae Hong Shin
  • , Won Jun Choi
  • , Kang Man Lee
  • , Hea Ok Kim
  • , Moon Woo Chun
  • , Hee Doo Kim
  • , Joong Hyup Kim

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

Original languageEnglish
Pages (from-to)589-592
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number5-8
DOIs
StatePublished - 2003

Keywords

  • Halo-neplanocin A
  • Mechanism-based inhibitor
  • S-Adenosylhomocysteine hydrolase

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