Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Lak Shin Jeong; Hyung Ryong Moon; Jae Gyu Park; Dae Hong Shin; Won Jun Choi; Kang Man Lee; Hea Ok Kim; Moon Woo Chun; Hee Doo Kim; Joong Hyup Kim

doi:10.1081/NCN-120021961

Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Lak Shin Jeong
, Hyung Ryong Moon
, Jae Gyu Park
, Dae Hong Shin
, Won Jun Choi
, Kang Man Lee
, Hea Ok Kim
, Moon Woo Chun
, Hee Doo Kim
, Joong Hyup Kim

Department of Pharmacy

Ewha Womans University
Seoul National University
Sookmyung Women's University
Korea Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

Original language	English
Pages (from-to)	589-592
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	22
Issue number	5-8
DOIs	https://doi.org/10.1081/NCN-120021961
State	Published - 2003

Keywords

Halo-neplanocin A
Mechanism-based inhibitor
S-Adenosylhomocysteine hydrolase

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10.1081/NCN-120021961

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title = "Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase",

abstract = "Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.",

keywords = "Halo-neplanocin A, Mechanism-based inhibitor, S-Adenosylhomocysteine hydrolase",

author = "Jeong, \{Lak Shin\} and Moon, \{Hyung Ryong\} and Park, \{Jae Gyu\} and Shin, \{Dae Hong\} and Choi, \{Won Jun\} and Lee, \{Kang Man\} and Kim, \{Hea Ok\} and Chun, \{Moon Woo\} and Kim, \{Hee Doo\} and Kim, \{Joong Hyup\}",

year = "2003",

doi = "10.1081/NCN-120021961",

language = "English",

volume = "22",

pages = "589--592",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

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TY - JOUR

T1 - Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

AU - Jeong, Lak Shin

AU - Moon, Hyung Ryong

AU - Park, Jae Gyu

AU - Shin, Dae Hong

AU - Choi, Won Jun

AU - Lee, Kang Man

AU - Kim, Hea Ok

AU - Chun, Moon Woo

AU - Kim, Hee Doo

AU - Kim, Joong Hyup

PY - 2003

Y1 - 2003

N2 - Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

AB - Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

KW - Halo-neplanocin A

KW - Mechanism-based inhibitor

KW - S-Adenosylhomocysteine hydrolase

UR - https://www.scopus.com/pages/publications/0141425747

U2 - 10.1081/NCN-120021961

DO - 10.1081/NCN-120021961

M3 - Article

C2 - 14565234

AN - SCOPUS:0141425747

SN - 1525-7770

VL - 22

SP - 589

EP - 592

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-8

ER -

Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Abstract

Keywords

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