TY - JOUR
T1 - Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy
T2 - Part II
AU - Yang, Jee Sun
AU - Song, Doona
AU - Ko, Won Jin
AU - Kim, Bunyea
AU - Kim, Bo Kyung
AU - Park, Song Kyu
AU - Won, Misun
AU - Lee, Kiho
AU - Lee, Kyeong
AU - Kim, Hwan Mook
AU - Han, Gyoonhee
PY - 2013
Y1 - 2013
N2 - A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.
AB - A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.
KW - Aliphatic amido-quaternary ammonium salts
KW - GTPase RAt Sarcoma (Ras)
KW - NSC126188
KW - Open-ring form of aliphatic amido-quaternary ammonium salts
KW - Perifosine
KW - RhoB
UR - http://www.scopus.com/inward/record.url?scp=84875932912&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2012.12.063
DO - 10.1016/j.ejmech.2012.12.063
M3 - Article
C2 - 23567950
AN - SCOPUS:84875932912
SN - 0223-5234
VL - 63
SP - 621
EP - 628
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
ER -