Abstract
In this study, we have successfully developed 3-[ 131I]iodo- tyrosine grafted Fe 3O 4@SiO 2 nanocomposites for dual potential tumor imaging agent for SPECT and MRI. Fe 3O 4 nanoparticle was synthesized through thermal decomposition and Fe 3O 4@SiO 2 was prepared by reverse microemulsion method. After conjugating aminopropyltriethoxysiliane, L-tyrosine was introduced by amide coupling reaction. Finally, [ 131I]iodide was labeled on L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite by aromatic iodination using chloramine-T.
Original language | English |
---|---|
Pages (from-to) | 1818-1821 |
Number of pages | 4 |
Journal | Journal of Nanoscience and Nanotechnology |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2011 |
Keywords
- 3-[ I]Iodo-L-Tyrosine
- MRI
- Magnetic nanoparticles
- Nanocomposite
- SPECT