Synthesis and characterization of 3-[ 131I]iodo-L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI)

Seung Il Park, Bob Jin Kwon, Jeong Hoon Park, Hyun Jung, Kook Hyun Yu

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

In this study, we have successfully developed 3-[ 131I]iodo- tyrosine grafted Fe 3O 4@SiO 2 nanocomposites for dual potential tumor imaging agent for SPECT and MRI. Fe 3O 4 nanoparticle was synthesized through thermal decomposition and Fe 3O 4@SiO 2 was prepared by reverse microemulsion method. After conjugating aminopropyltriethoxysiliane, L-tyrosine was introduced by amide coupling reaction. Finally, [ 131I]iodide was labeled on L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite by aromatic iodination using chloramine-T.

Original languageEnglish
Pages (from-to)1818-1821
Number of pages4
JournalJournal of Nanoscience and Nanotechnology
Volume11
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • 3-[ I]Iodo-L-Tyrosine
  • MRI
  • Magnetic nanoparticles
  • Nanocomposite
  • SPECT

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