Synthesis and characterization of 3-[ 131I]iodo-L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI)

Seung Il Park; Bob Jin Kwon; Jeong Hoon Park; Hyun Jung; Kook Hyun Yu

doi:10.1166/jnn.2011.3416

Synthesis and characterization of 3-[ ¹³¹I]iodo-L-tyrosine grafted Fe ₃O ₄@SiO ₂ nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI)

Seung Il Park
, Bob Jin Kwon
, Jeong Hoon Park
, Hyun Jung
, Kook Hyun Yu

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In this study, we have successfully developed 3-[ ¹³¹I]iodo- tyrosine grafted Fe ₃O ₄@SiO ₂ nanocomposites for dual potential tumor imaging agent for SPECT and MRI. Fe ₃O ₄ nanoparticle was synthesized through thermal decomposition and Fe ₃O ₄@SiO ₂ was prepared by reverse microemulsion method. After conjugating aminopropyltriethoxysiliane, L-tyrosine was introduced by amide coupling reaction. Finally, [ ¹³¹I]iodide was labeled on L-tyrosine grafted Fe ₃O ₄@SiO ₂ nanocomposite by aromatic iodination using chloramine-T.

Original language	English
Pages (from-to)	1818-1821
Number of pages	4
Journal	Journal of Nanoscience and Nanotechnology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1166/jnn.2011.3416
State	Published - Feb 2011

Keywords

3-[ I]Iodo-L-Tyrosine
MRI
Magnetic nanoparticles
Nanocomposite
SPECT

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10.1166/jnn.2011.3416

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title = "Synthesis and characterization of 3-[ 131I]iodo-L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI)",

abstract = "In this study, we have successfully developed 3-[ 131I]iodo- tyrosine grafted Fe 3O 4@SiO 2 nanocomposites for dual potential tumor imaging agent for SPECT and MRI. Fe 3O 4 nanoparticle was synthesized through thermal decomposition and Fe 3O 4@SiO 2 was prepared by reverse microemulsion method. After conjugating aminopropyltriethoxysiliane, L-tyrosine was introduced by amide coupling reaction. Finally, [ 131I]iodide was labeled on L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite by aromatic iodination using chloramine-T.",

keywords = "3-[ I]Iodo-L-Tyrosine, MRI, Magnetic nanoparticles, Nanocomposite, SPECT",

author = "Park, \{Seung Il\} and Kwon, \{Bob Jin\} and Park, \{Jeong Hoon\} and Hyun Jung and Yu, \{Kook Hyun\}",

year = "2011",

month = feb,

doi = "10.1166/jnn.2011.3416",

language = "English",

volume = "11",

pages = "1818--1821",

journal = "Journal of Nanoscience and Nanotechnology",

issn = "1533-4880",

publisher = "American Scientific Publishers",

number = "2",

}

Synthesis and characterization of 3-[ ¹³¹I]iodo-L-tyrosine grafted Fe ₃O ₄@SiO ₂ nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). / Park, Seung Il; Kwon, Bob Jin; Park, Jeong Hoon et al.
In: Journal of Nanoscience and Nanotechnology, Vol. 11, No. 2, 02.2011, p. 1818-1821.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and characterization of 3-[ 131I]iodo-L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI)

AU - Park, Seung Il

AU - Kwon, Bob Jin

AU - Park, Jeong Hoon

AU - Jung, Hyun

AU - Yu, Kook Hyun

PY - 2011/2

Y1 - 2011/2

N2 - In this study, we have successfully developed 3-[ 131I]iodo- tyrosine grafted Fe 3O 4@SiO 2 nanocomposites for dual potential tumor imaging agent for SPECT and MRI. Fe 3O 4 nanoparticle was synthesized through thermal decomposition and Fe 3O 4@SiO 2 was prepared by reverse microemulsion method. After conjugating aminopropyltriethoxysiliane, L-tyrosine was introduced by amide coupling reaction. Finally, [ 131I]iodide was labeled on L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite by aromatic iodination using chloramine-T.

AB - In this study, we have successfully developed 3-[ 131I]iodo- tyrosine grafted Fe 3O 4@SiO 2 nanocomposites for dual potential tumor imaging agent for SPECT and MRI. Fe 3O 4 nanoparticle was synthesized through thermal decomposition and Fe 3O 4@SiO 2 was prepared by reverse microemulsion method. After conjugating aminopropyltriethoxysiliane, L-tyrosine was introduced by amide coupling reaction. Finally, [ 131I]iodide was labeled on L-tyrosine grafted Fe 3O 4@SiO 2 nanocomposite by aromatic iodination using chloramine-T.

KW - 3-[ I]Iodo-L-Tyrosine

KW - MRI

KW - Magnetic nanoparticles

KW - Nanocomposite

KW - SPECT

UR - https://www.scopus.com/pages/publications/79955004078

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DO - 10.1166/jnn.2011.3416

M3 - Article

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AN - SCOPUS:79955004078

SN - 1533-4880

VL - 11

SP - 1818

EP - 1821

JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

IS - 2

ER -

Synthesis and characterization of 3-[ ¹³¹I]iodo-L-tyrosine grafted Fe ₃O ₄@SiO ₂ nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI)

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Keywords

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