Synthesis and in vitro cytotoxicity of cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)

Dae Kee Kim; Young Woo Kim; Hun Taek Kim; Key H. Kim

doi:10.1016/0960-894X(96)00088-1

Synthesis and in vitro cytotoxicity of cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)

Dae Kee Kim
, Young Woo Kim
, Hun Taek Kim
, Key H. Kim

Department of Pharmacy

Life Science Research Center

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

cis-Dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxyp yrrolidine]-platinum(II) (1) and cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-dihydroxypyrrolidine]platinu m(II) (2) have been synthesized and evaluated for their in vitro cytotoxicity against cisplatin-sensitive and -resistant L1210 murine leukemia cell lines and human tumor cell lines. The complex 1 showed high cytotoxicity against human cancer cell lines, A 549, SK-OV-3, and XF 498 and much lower cross-resistance against cisplatin-resistant L1210 cells than cisplatin and carboplatin.

Original language	English
Pages (from-to)	643-646
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0960-894X(96)00088-1
State	Published - 19 Mar 1996

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10.1016/0960-894X(96)00088-1

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title = "Synthesis and in vitro cytotoxicity of cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)",

abstract = "cis-Dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxyp yrrolidine]-platinum(II) (1) and cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-dihydroxypyrrolidine]platinu m(II) (2) have been synthesized and evaluated for their in vitro cytotoxicity against cisplatin-sensitive and -resistant L1210 murine leukemia cell lines and human tumor cell lines. The complex 1 showed high cytotoxicity against human cancer cell lines, A 549, SK-OV-3, and XF 498 and much lower cross-resistance against cisplatin-resistant L1210 cells than cisplatin and carboplatin.",

author = "Kim, \{Dae Kee\} and Kim, \{Young Woo\} and Kim, \{Hun Taek\} and Kim, \{Key H.\}",

year = "1996",

month = mar,

day = "19",

doi = "10.1016/0960-894X(96)00088-1",

language = "English",

volume = "6",

pages = "643--646",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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number = "6",

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TY - JOUR

T1 - Synthesis and in vitro cytotoxicity of cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)

AU - Kim, Dae Kee

AU - Kim, Young Woo

AU - Kim, Hun Taek

AU - Kim, Key H.

PY - 1996/3/19

Y1 - 1996/3/19

N2 - cis-Dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxyp yrrolidine]-platinum(II) (1) and cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-dihydroxypyrrolidine]platinu m(II) (2) have been synthesized and evaluated for their in vitro cytotoxicity against cisplatin-sensitive and -resistant L1210 murine leukemia cell lines and human tumor cell lines. The complex 1 showed high cytotoxicity against human cancer cell lines, A 549, SK-OV-3, and XF 498 and much lower cross-resistance against cisplatin-resistant L1210 cells than cisplatin and carboplatin.

AB - cis-Dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxyp yrrolidine]-platinum(II) (1) and cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-dihydroxypyrrolidine]platinu m(II) (2) have been synthesized and evaluated for their in vitro cytotoxicity against cisplatin-sensitive and -resistant L1210 murine leukemia cell lines and human tumor cell lines. The complex 1 showed high cytotoxicity against human cancer cell lines, A 549, SK-OV-3, and XF 498 and much lower cross-resistance against cisplatin-resistant L1210 cells than cisplatin and carboplatin.

UR - https://www.scopus.com/pages/publications/0029932154

U2 - 10.1016/0960-894X(96)00088-1

DO - 10.1016/0960-894X(96)00088-1

M3 - Article

AN - SCOPUS:0029932154

SN - 0960-894X

VL - 6

SP - 643

EP - 646

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Synthesis and in vitro cytotoxicity of cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)

Abstract

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