Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents

Xiaojuan Pei, Won Jun Choi, Yu Min Kim, Long Xuan Zhao, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.

Original languageEnglish
Pages (from-to)843-849
Number of pages7
JournalArchives of Pharmacal Research
Volume31
Issue number7
DOIs
StatePublished - Jul 2008

Keywords

  • 3'-C-hydroxymethyl nucleosides
  • Anti-hepatitis C virus (HCV) activity
  • Neighboring group effect
  • Stereoselective Grignard reaction

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