Abstract
On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.
Original language | English |
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Pages (from-to) | 843-849 |
Number of pages | 7 |
Journal | Archives of Pharmacal Research |
Volume | 31 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2008 |
Keywords
- 3'-C-hydroxymethyl nucleosides
- Anti-hepatitis C virus (HCV) activity
- Neighboring group effect
- Stereoselective Grignard reaction