Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents

Xiaojuan Pei; Won Jun Choi; Yu Min Kim; Long Xuan Zhao; Lak Shin Jeong

doi:10.1007/s12272-001-1236-z

Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents

Xiaojuan Pei
, Won Jun Choi
, Yu Min Kim
, Long Xuan Zhao
, Lak Shin Jeong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.

Original language	English
Pages (from-to)	843-849
Number of pages	7
Journal	Archives of Pharmacal Research
Volume	31
Issue number	7
DOIs	https://doi.org/10.1007/s12272-001-1236-z
State	Published - Jul 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3'-C-hydroxymethyl nucleosides
Anti-hepatitis C virus (HCV) activity
Neighboring group effect
Stereoselective Grignard reaction

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10.1007/s12272-001-1236-z

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title = "Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents",

abstract = "On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.",

keywords = "3'-C-hydroxymethyl nucleosides, Anti-hepatitis C virus (HCV) activity, Neighboring group effect, Stereoselective Grignard reaction",

author = "Xiaojuan Pei and Choi, \{Won Jun\} and Kim, \{Yu Min\} and Zhao, \{Long Xuan\} and Jeong, \{Lak Shin\}",

year = "2008",

month = jul,

doi = "10.1007/s12272-001-1236-z",

language = "English",

volume = "31",

pages = "843--849",

journal = "Archives of Pharmacal Research",

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T1 - Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents

AU - Pei, Xiaojuan

AU - Choi, Won Jun

AU - Kim, Yu Min

AU - Zhao, Long Xuan

AU - Jeong, Lak Shin

PY - 2008/7

Y1 - 2008/7

N2 - On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.

AB - On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.

KW - 3'-C-hydroxymethyl nucleosides

KW - Anti-hepatitis C virus (HCV) activity

KW - Neighboring group effect

KW - Stereoselective Grignard reaction

UR - https://www.scopus.com/pages/publications/49749093968

U2 - 10.1007/s12272-001-1236-z

DO - 10.1007/s12272-001-1236-z

M3 - Article

C2 - 18704325

AN - SCOPUS:49749093968

SN - 0253-6269

VL - 31

SP - 843

EP - 849

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 7

ER -

Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents

Abstract

UN SDGs

Keywords

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