Synthesis of acyl thiourea derivatives of 7-trifluoromethyl-2-pyridylquinazolin-4(3H)-one as anticancer agents

Bhupendra M. Mistry, Han Seung Shin, Muthuraman Pandurangan, Rahul V. Patel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A new series of 7-trifluoromethyl-2-pyridylquinazolin-4(3H)-one-based acyl thiourea derivatives has been generated and tested for their cytotoxicity towards human ovarian cancer (SK-OV-3), cervical cancer (HeLa), renal cancer (Caki-2) cell lines, as well as noncancerous a human umbilical vein endothelial cell (HUVEC) line. The new thiourea derivatives were found to be promisingly cytotoxic towards the cancerous cell lines. Changing the substituent at the thiourea linkage led to variations in the cytotoxic potential of the resultant derivatives towards specific cell lines. Molecules with fluorine functionality and multiple pyridyl moieties showed encouraging anticancer effects and could be used as a platform for the design of further chemotherapeutic agents. The proposed structures of the products were ascertained through FTIR, mass, 1H NMR and 13C NMR spectra and elemental analyses.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalJournal of Chemical Research
Volume41
Issue number10
DOIs
StatePublished - Oct 2017

Keywords

  • Anticancer agents
  • Cytotoxicity
  • Drug design
  • MTT assay
  • Quinazolin-4(3H)-one
  • Thiourea

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