Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Eun Young Song; Navneet Kaur; Mi Young Park; Yinglan Jin; Kyeong Lee; Guncheol Kim; Ki Youn Lee; Jee Sun Yang; Jae Hong Shin; Ky Youb Nam; Kyoung Tai No; Gyoonhee Han

doi:10.1016/j.ejmech.2007.10.008

Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Eun Young Song, Navneet Kaur, Mi Young Park, Yinglan Jin, Kyeong Lee, Guncheol Kim, Ki Youn Lee, Jee Sun Yang, Jae Hong Shin, Ky Youb Nam, Kyoung Tai No, Gyoonhee Han

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

Original language	English
Pages (from-to)	1519-1524
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	43
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2007.10.008
State	Published - Jul 2008

Keywords

Antiproliferative
Benzothiazole derivatives
Raf-1 activity

Access to Document

10.1016/j.ejmech.2007.10.008

Cite this

@article{ecddf9aaffda4f72ac213a4ceaab3743,

title = "Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor",

abstract = "A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.",

keywords = "Antiproliferative, Benzothiazole derivatives, Raf-1 activity",

author = "Song, {Eun Young} and Navneet Kaur and Park, {Mi Young} and Yinglan Jin and Kyeong Lee and Guncheol Kim and Lee, {Ki Youn} and Yang, {Jee Sun} and Shin, {Jae Hong} and Nam, {Ky Youb} and No, {Kyoung Tai} and Gyoonhee Han",

year = "2008",

month = jul,

doi = "10.1016/j.ejmech.2007.10.008",

language = "English",

volume = "43",

pages = "1519--1524",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "7",

}

TY - JOUR

T1 - Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

AU - Song, Eun Young

AU - Kaur, Navneet

AU - Park, Mi Young

AU - Jin, Yinglan

AU - Lee, Kyeong

AU - Kim, Guncheol

AU - Lee, Ki Youn

AU - Yang, Jee Sun

AU - Shin, Jae Hong

AU - Nam, Ky Youb

AU - No, Kyoung Tai

AU - Han, Gyoonhee

PY - 2008/7

Y1 - 2008/7

N2 - A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

AB - A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

KW - Antiproliferative

KW - Benzothiazole derivatives

KW - Raf-1 activity

UR - http://www.scopus.com/inward/record.url?scp=45849124657&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2007.10.008

DO - 10.1016/j.ejmech.2007.10.008

M3 - Article

C2 - 18023932

AN - SCOPUS:45849124657

SN - 0223-5234

VL - 43

SP - 1519

EP - 1524

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this