Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Eun Young Song; Navneet Kaur; Mi Young Park; Yinglan Jin; Kyeong Lee; Guncheol Kim; Ki Youn Lee; Jee Sun Yang; Jae Hong Shin; Ky Youb Nam; Kyoung Tai No; Gyoonhee Han

doi:10.1016/j.ejmech.2007.10.008

Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Eun Young Song
, Navneet Kaur
, Mi Young Park
, Yinglan Jin
, Kyeong Lee
, Guncheol Kim
, Ki Youn Lee
, Jee Sun Yang
, Jae Hong Shin
, Ky Youb Nam
, Kyoung Tai No
, Gyoonhee Han

Department of Pharmacy

Korea Research Institute of Bioscience and Biotechnology
Chungnam National University
Yonsei University
Bioinformatics and Molecular Design Research Center (BMDRC)

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

Original language	English
Pages (from-to)	1519-1524
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	43
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2007.10.008
State	Published - Jul 2008

Keywords

Antiproliferative
Benzothiazole derivatives
Raf-1 activity

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10.1016/j.ejmech.2007.10.008

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title = "Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor",

abstract = "A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.",

keywords = "Antiproliferative, Benzothiazole derivatives, Raf-1 activity",

author = "Song, \{Eun Young\} and Navneet Kaur and Park, \{Mi Young\} and Yinglan Jin and Kyeong Lee and Guncheol Kim and Lee, \{Ki Youn\} and Yang, \{Jee Sun\} and Shin, \{Jae Hong\} and Nam, \{Ky Youb\} and No, \{Kyoung Tai\} and Gyoonhee Han",

year = "2008",

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doi = "10.1016/j.ejmech.2007.10.008",

language = "English",

volume = "43",

pages = "1519--1524",

journal = "European Journal of Medicinal Chemistry",

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TY - JOUR

T1 - Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

AU - Song, Eun Young

AU - Kaur, Navneet

AU - Park, Mi Young

AU - Jin, Yinglan

AU - Lee, Kyeong

AU - Kim, Guncheol

AU - Lee, Ki Youn

AU - Yang, Jee Sun

AU - Shin, Jae Hong

AU - Nam, Ky Youb

AU - No, Kyoung Tai

AU - Han, Gyoonhee

PY - 2008/7

Y1 - 2008/7

N2 - A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

AB - A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

KW - Antiproliferative

KW - Benzothiazole derivatives

KW - Raf-1 activity

UR - https://www.scopus.com/pages/publications/45849124657

U2 - 10.1016/j.ejmech.2007.10.008

DO - 10.1016/j.ejmech.2007.10.008

M3 - Article

C2 - 18023932

AN - SCOPUS:45849124657

SN - 0223-5234

VL - 43

SP - 1519

EP - 1524

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Abstract

Keywords

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