Abstract
Stereoselective synthesis of apio-neplanocin A and its related purine nucleosides which combined the properties of neplanocin A and apio nucleoside was achieved, starting from D-ribose via regioselective hydroxymethylation and ring-closing metathesis (RCM) as key steps. However, all synthesized compounds did not show significant inhibitory activity against S-adenosylhomocysteine hydrolase, unlike neplanocin A.
Original language | English |
---|---|
Pages (from-to) | 15-16 |
Number of pages | 2 |
Journal | Nucleic acids research. Supplement (2001) |
Issue number | 3 |
DOIs | |
State | Published - 2003 |