Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.

Jeong A. Lee, Byul Nae Yoo, Won Jun Choi, Hyung Ryong Moon, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Stereoselective synthesis of apio-neplanocin A and its related purine nucleosides which combined the properties of neplanocin A and apio nucleoside was achieved, starting from D-ribose via regioselective hydroxymethylation and ring-closing metathesis (RCM) as key steps. However, all synthesized compounds did not show significant inhibitory activity against S-adenosylhomocysteine hydrolase, unlike neplanocin A.

Original languageEnglish
Pages (from-to)15-16
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number3
DOIs
StatePublished - 2003

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