Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.

Jeong A. Lee; Byul Nae Yoo; Won Jun Choi; Hyung Ryong Moon; Lak Shin Jeong

doi:10.1093/nass/3.1.15

Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.

Jeong A. Lee
, Byul Nae Yoo
, Won Jun Choi
, Hyung Ryong Moon
, Lak Shin Jeong

Department of Pharmacy

Ewha Womans University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Stereoselective synthesis of apio-neplanocin A and its related purine nucleosides which combined the properties of neplanocin A and apio nucleoside was achieved, starting from D-ribose via regioselective hydroxymethylation and ring-closing metathesis (RCM) as key steps. However, all synthesized compounds did not show significant inhibitory activity against S-adenosylhomocysteine hydrolase, unlike neplanocin A.

Original language	English
Pages (from-to)	15-16
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	3
DOIs	https://doi.org/10.1093/nass/3.1.15
State	Published - 2003

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10.1093/nass/3.1.15

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title = "Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.",

abstract = "Stereoselective synthesis of apio-neplanocin A and its related purine nucleosides which combined the properties of neplanocin A and apio nucleoside was achieved, starting from D-ribose via regioselective hydroxymethylation and ring-closing metathesis (RCM) as key steps. However, all synthesized compounds did not show significant inhibitory activity against S-adenosylhomocysteine hydrolase, unlike neplanocin A.",

author = "Lee, \{Jeong A.\} and Yoo, \{Byul Nae\} and Choi, \{Won Jun\} and Moon, \{Hyung Ryong\} and Jeong, \{Lak Shin\}",

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language = "English",

pages = "15--16",

journal = "Nucleic acids research. Supplement (2001)",

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T1 - Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.

AU - Lee, Jeong A.

AU - Yoo, Byul Nae

AU - Choi, Won Jun

AU - Moon, Hyung Ryong

AU - Jeong, Lak Shin

PY - 2003

Y1 - 2003

N2 - Stereoselective synthesis of apio-neplanocin A and its related purine nucleosides which combined the properties of neplanocin A and apio nucleoside was achieved, starting from D-ribose via regioselective hydroxymethylation and ring-closing metathesis (RCM) as key steps. However, all synthesized compounds did not show significant inhibitory activity against S-adenosylhomocysteine hydrolase, unlike neplanocin A.

AB - Stereoselective synthesis of apio-neplanocin A and its related purine nucleosides which combined the properties of neplanocin A and apio nucleoside was achieved, starting from D-ribose via regioselective hydroxymethylation and ring-closing metathesis (RCM) as key steps. However, all synthesized compounds did not show significant inhibitory activity against S-adenosylhomocysteine hydrolase, unlike neplanocin A.

UR - https://www.scopus.com/pages/publications/0142212336

U2 - 10.1093/nass/3.1.15

DO - 10.1093/nass/3.1.15

M3 - Article

C2 - 14510357

AN - SCOPUS:0142212336

SP - 15

EP - 16

JO - Nucleic acids research. Supplement (2001)

JF - Nucleic acids research. Supplement (2001)

IS - 3

ER -

Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.

Abstract

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