Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination cancer therapy

Seounghun Kang, Yu Lim Hong, Bon Cheol Ku, Seunghyun Lee, Seongwoo Ryu, Dal Hee Min, Hongje Jang, Young Kwan Kim

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A therapeutic reduced graphene oxide (RGO) is synthesized by using fucoidan (Fu) as the reducing and surface functionalizing agent. The synthesized Fu-RGO exhibits promising characteristics for therapeutic applications such as high dispersity in aqueous media, biocompatibility, selective cytotoxicity to cancer cells, high loading capacity of the anticancer drug, and photothermal conversion effect. Therefore, Fu-GO is successfully harnessed as a combinatorial cancer treatment platform through bio-functional (Fu), chemo (doxorubicin (Dox)) and photothermal (RGO with near-infrared irradiation) modalities.

Original languageEnglish
Article number475604
JournalNanotechnology
Volume29
Issue number47
DOIs
StatePublished - 27 Sep 2018

Keywords

  • cancer therapy
  • graphene oxide
  • reduction
  • surface functionalization
  • ucoidan

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