TY - JOUR
T1 - Synthesis of chitosan based reduced graphene oxide-CeO2 nanocomposites for drug delivery and antibacterial applications
AU - Sanmugam, Anandhavelu
AU - Abbishek, S.
AU - Kumar, S. Logesh
AU - Sairam, Ananda Babu
AU - Palem, Vishnu Vardhan
AU - Kumar, Raju Suresh
AU - Almansour, Abdulrahman I.
AU - Arumugam, Natarajan
AU - Vikraman, Dhanasekaran
N1 - Publisher Copyright:
© 2023
PY - 2023/9
Y1 - 2023/9
N2 - In this study, the unique characteristics of chitosan, reduced graphene oxide (rGO) and cerium oxide (CeO2) based hybrid bionano-composites make a carrier for various drug delivery and antimicrobial applications. The recent literatures shown that addition of biopolymers to rGO and CeO2 based nanocomposites exhibit excellent performance in design and development of biosensors, wound dressings, electrodes, microfluidic chips, drug delivery systems and energy storage applications. Chitosan (CS), reduced graphene oxide (rGO) mixed with cerium oxide (CeO2) to form CS-rGO and CS-rGO-CeO2 hybrid bionano-composites using precipitation method. The physiochemical characterization of casted nanocomposite sheet was done using FTIR, XRD, UV–Vis spectrum, SEM and TGA. The XRD results of CS-rGO-CeO2 revealed that the nanoparticle was found to be crystalline structure. FTIR revealed that nitrogen functionalities of CS interacted with rGO-CeO2 to form hybrid nanocomposites. The thermal gravimetric analysis (TGA) showed that the CS-rGO-CeO2 has better thermal stability up to 550 °C. The SEM confirms the surface morphology of CS-rGO-CeO2 has large surface area with smooth surface. Moreover, the antibacterial properties of nanocomposites exhibit excellent zone of inhibition against Staphylococcus aureus and Escherichia coli. The NIH3T3 cell line evaluations showed superior cell adhesion on hybrid nanocomposites. Hence bionano-composite based on CS, rGO and CeO2 are potential biomaterials for drug delivery and antibacterial applications.
AB - In this study, the unique characteristics of chitosan, reduced graphene oxide (rGO) and cerium oxide (CeO2) based hybrid bionano-composites make a carrier for various drug delivery and antimicrobial applications. The recent literatures shown that addition of biopolymers to rGO and CeO2 based nanocomposites exhibit excellent performance in design and development of biosensors, wound dressings, electrodes, microfluidic chips, drug delivery systems and energy storage applications. Chitosan (CS), reduced graphene oxide (rGO) mixed with cerium oxide (CeO2) to form CS-rGO and CS-rGO-CeO2 hybrid bionano-composites using precipitation method. The physiochemical characterization of casted nanocomposite sheet was done using FTIR, XRD, UV–Vis spectrum, SEM and TGA. The XRD results of CS-rGO-CeO2 revealed that the nanoparticle was found to be crystalline structure. FTIR revealed that nitrogen functionalities of CS interacted with rGO-CeO2 to form hybrid nanocomposites. The thermal gravimetric analysis (TGA) showed that the CS-rGO-CeO2 has better thermal stability up to 550 °C. The SEM confirms the surface morphology of CS-rGO-CeO2 has large surface area with smooth surface. Moreover, the antibacterial properties of nanocomposites exhibit excellent zone of inhibition against Staphylococcus aureus and Escherichia coli. The NIH3T3 cell line evaluations showed superior cell adhesion on hybrid nanocomposites. Hence bionano-composite based on CS, rGO and CeO2 are potential biomaterials for drug delivery and antibacterial applications.
KW - Antibacterial
KW - Cerium Oxide
KW - Chitosan
KW - Drug delivery
KW - Reduced Graphene Oxide
UR - http://www.scopus.com/inward/record.url?scp=85165356286&partnerID=8YFLogxK
U2 - 10.1016/j.jmbbm.2023.106033
DO - 10.1016/j.jmbbm.2023.106033
M3 - Article
C2 - 37478544
AN - SCOPUS:85165356286
SN - 1751-6161
VL - 145
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
M1 - 106033
ER -