Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

Lak Shin Jeong; Jae Gyu Park; Won Jun Choi; Hyung Ryong Moon; Kang Man Lee; Hea Ok Kim; Hee Doo Kim; Moon Woo Chun; Hea Young Park; Kilhyoun Kim; Yhun Y. Sheen

doi:10.1081/NCN-120022686

Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

Lak Shin Jeong, Jae Gyu Park, Won Jun Choi, Hyung Ryong Moon, Kang Man Lee, Hea Ok Kim, Hee Doo Kim, Moon Woo Chun, Hea Young Park, Kilhyoun Kim, Yhun Y. Sheen

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.

Original language	English
Pages (from-to)	919-921
Number of pages	3
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	22
Issue number	5-8
DOIs	https://doi.org/10.1081/NCN-120022686
State	Published - 2003

Keywords

Halogenated 9-(dihydroxycyclopent-4′ -enyl) adenines
S-Adenosylhomocysteine hydrolase

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10.1081/NCN-120022686

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Jeong, L. S., Park, J. G., Choi, W. J., Moon, H. R., Lee, K. M., Kim, H. O., Kim, H. D., Chun, M. W., Park, H. Y., Kim, K., & Sheen, Y. Y. (2003). Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase. Nucleosides, Nucleotides and Nucleic Acids, 22(5-8), 919-921. https://doi.org/10.1081/NCN-120022686

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abstract = "Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.",

keywords = "Halogenated 9-(dihydroxycyclopent-4′ -enyl) adenines, S-Adenosylhomocysteine hydrolase",

author = "Jeong, {Lak Shin} and Park, {Jae Gyu} and Choi, {Won Jun} and Moon, {Hyung Ryong} and Lee, {Kang Man} and Kim, {Hea Ok} and Kim, {Hee Doo} and Chun, {Moon Woo} and Park, {Hea Young} and Kilhyoun Kim and Sheen, {Yhun Y.}",

year = "2003",

doi = "10.1081/NCN-120022686",

language = "English",

volume = "22",

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T1 - Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

AU - Jeong, Lak Shin

AU - Park, Jae Gyu

AU - Choi, Won Jun

AU - Moon, Hyung Ryong

AU - Lee, Kang Man

AU - Kim, Hea Ok

AU - Kim, Hee Doo

AU - Chun, Moon Woo

AU - Park, Hea Young

AU - Kim, Kilhyoun

AU - Sheen, Yhun Y.

PY - 2003

Y1 - 2003

N2 - Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.

AB - Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.

KW - Halogenated 9-(dihydroxycyclopent-4′ -enyl) adenines

KW - S-Adenosylhomocysteine hydrolase

UR - http://www.scopus.com/inward/record.url?scp=0141425535&partnerID=8YFLogxK

U2 - 10.1081/NCN-120022686

DO - 10.1081/NCN-120022686

M3 - Article

C2 - 14565311

AN - SCOPUS:0141425535

SN - 1525-7770

VL - 22

SP - 919

EP - 921

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-8

ER -

Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

Abstract

Keywords

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