Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

Lak Shin Jeong; Jae Gyu Park; Won Jun Choi; Hyung Ryong Moon; Kang Man Lee; Hea Ok Kim; Hee Doo Kim; Moon Woo Chun; Hea Young Park; Kilhyoun Kim; Yhun Y. Sheen

doi:10.1081/NCN-120022686

Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

Lak Shin Jeong
, Jae Gyu Park
, Won Jun Choi
, Hyung Ryong Moon
, Kang Man Lee
, Hea Ok Kim
, Hee Doo Kim
, Moon Woo Chun
, Hea Young Park
, Kilhyoun Kim
, Yhun Y. Sheen

Department of Pharmacy

Ewha Womans University
Seoul National University
Sookmyung Women's University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.

Original language	English
Pages (from-to)	919-921
Number of pages	3
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	22
Issue number	5-8
DOIs	https://doi.org/10.1081/NCN-120022686
State	Published - 2003

Keywords

Halogenated 9-(dihydroxycyclopent-4′ -enyl) adenines
S-Adenosylhomocysteine hydrolase

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10.1081/NCN-120022686

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Jeong, L. S., Park, J. G., Choi, W. J., Moon, H. R., Lee, K. M., Kim, H. O., Kim, H. D., Chun, M. W., Park, H. Y., Kim, K., & Sheen, Y. Y. (2003). Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase. Nucleosides, Nucleotides and Nucleic Acids, 22(5-8), 919-921. https://doi.org/10.1081/NCN-120022686

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title = "Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase",

abstract = "Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.",

keywords = "Halogenated 9-(dihydroxycyclopent-4′ -enyl) adenines, S-Adenosylhomocysteine hydrolase",

author = "Jeong, \{Lak Shin\} and Park, \{Jae Gyu\} and Choi, \{Won Jun\} and Moon, \{Hyung Ryong\} and Lee, \{Kang Man\} and Kim, \{Hea Ok\} and Kim, \{Hee Doo\} and Chun, \{Moon Woo\} and Park, \{Hea Young\} and Kilhyoun Kim and Sheen, \{Yhun Y.\}",

year = "2003",

doi = "10.1081/NCN-120022686",

language = "English",

volume = "22",

pages = "919--921",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

publisher = "Taylor and Francis Ltd.",

number = "5-8",

}

TY - JOUR

T1 - Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

AU - Jeong, Lak Shin

AU - Park, Jae Gyu

AU - Choi, Won Jun

AU - Moon, Hyung Ryong

AU - Lee, Kang Man

AU - Kim, Hea Ok

AU - Kim, Hee Doo

AU - Chun, Moon Woo

AU - Park, Hea Young

AU - Kim, Kilhyoun

AU - Sheen, Yhun Y.

PY - 2003

Y1 - 2003

N2 - Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.

AB - Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.

KW - Halogenated 9-(dihydroxycyclopent-4′ -enyl) adenines

KW - S-Adenosylhomocysteine hydrolase

UR - https://www.scopus.com/pages/publications/0141425535

U2 - 10.1081/NCN-120022686

DO - 10.1081/NCN-120022686

M3 - Article

C2 - 14565311

AN - SCOPUS:0141425535

SN - 1525-7770

VL - 22

SP - 919

EP - 921

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-8

ER -

Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

Abstract

Keywords

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