Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase

  • Lak Shin Jeong
  • , Jae Gyu Park
  • , Won Jun Choi
  • , Hyung Ryong Moon
  • , Kang Man Lee
  • , Hea Ok Kim
  • , Hee Doo Kim
  • , Moon Woo Chun
  • , Hea Young Park
  • , Kilhyoun Kim
  • , Yhun Y. Sheen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.

Original languageEnglish
Pages (from-to)919-921
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number5-8
DOIs
StatePublished - 2003

Keywords

  • Halogenated 9-(dihydroxycyclopent-4′ -enyl) adenines
  • S-Adenosylhomocysteine hydrolase

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