TY - JOUR
T1 - Synthesis of nano-cuboidal gold particles for effective antimicrobial property against clinical human pathogens
AU - Murphin Kumar, Paskalis Sahaya
AU - MubarakAli, Davoodbasha
AU - Saratale, Rijuta Ganesh
AU - Saratale, Ganesh Dattatraya
AU - Pugazhendhi, Arivalagan
AU - Gopalakrishnan, Kumar
AU - Thajuddin, Nooruddin
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12
Y1 - 2017/12
N2 - Algae could offer a potential source of fine chemicals, pharmaceuticals and biofuels. In this study, a green synthesis of dispersed cuboidal gold nanoparticles (AuNPs) was achieved using red algae, Gelidium amansii reacted with HAuCl4. It was found to be 4–7 nm sized cubical nanoparticles with aspect ratio of 1.4 were synthesized using 0.5 mM of HAuCl4 by HRSEM analysis. The crystalline planes (111), (200), (220), (311) and elemental signal of gold was observed by XRD and EDS respectively. The major constitutes, galactose and 3,6-anhydrogalactose in the alga played a critical role in the synthesis of crystalline AuNPs with cubical dimension. Further, the antibacterial potential of synthesized AuNPs was tested against human pathogens, Escherichia coli and Staphylococcus aureus. The synthesized AuNPs found biocompatible up to 100 ppm and high concentration showed an inhibition against cancer cell. This novel report could be helped to exploration of bioresources to material synthesis for the application of biosensor and biomedical application.
AB - Algae could offer a potential source of fine chemicals, pharmaceuticals and biofuels. In this study, a green synthesis of dispersed cuboidal gold nanoparticles (AuNPs) was achieved using red algae, Gelidium amansii reacted with HAuCl4. It was found to be 4–7 nm sized cubical nanoparticles with aspect ratio of 1.4 were synthesized using 0.5 mM of HAuCl4 by HRSEM analysis. The crystalline planes (111), (200), (220), (311) and elemental signal of gold was observed by XRD and EDS respectively. The major constitutes, galactose and 3,6-anhydrogalactose in the alga played a critical role in the synthesis of crystalline AuNPs with cubical dimension. Further, the antibacterial potential of synthesized AuNPs was tested against human pathogens, Escherichia coli and Staphylococcus aureus. The synthesized AuNPs found biocompatible up to 100 ppm and high concentration showed an inhibition against cancer cell. This novel report could be helped to exploration of bioresources to material synthesis for the application of biosensor and biomedical application.
KW - Algae
KW - Antimicrobial
KW - AuNPs
KW - HRTEM
KW - Pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=85031892785&partnerID=8YFLogxK
U2 - 10.1016/j.micpath.2017.10.032
DO - 10.1016/j.micpath.2017.10.032
M3 - Article
C2 - 29056495
AN - SCOPUS:85031892785
SN - 0882-4010
VL - 113
SP - 68
EP - 73
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
ER -
