Synthesis of novel diaryl ethers and their evaluation as antimitotic agents

Jin Kyung In, Mi Sung Lee, Jung Eun Yang, Jae Hwan Kwak, Heesoon Lee, Shanthaveerappa K. Boovanahalli, Kyeong Lee, Soo Jin Kim, Seung Kee Moon, Sungsook Lee, Nam Song Choi, Soon Kil Ahn, Jae Kyung Jung

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A series of novel diaryl ethers possessing various functional groups were synthesized and evaluated for antiproliferative activity in human myeloid leukemia HL-60 cells. Among the compounds examined, compounds 10, 17, 20, 24, and 33 showed moderate to potent antiproliferative activity. These derivatives were further examined in terms of their abilities to inhibit tubulin polymerization; however, all of the tested compounds were relatively ineffective. The reference compound E7010 with an IC50 of 0.34 μM exhibited potent antiproliferative activity and significantly inhibited tubulin polymerization in a dose-dependent manner.

Original languageEnglish
Pages (from-to)1799-1802
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number6
DOIs
StatePublished - 15 Mar 2007

Keywords

  • Antimitotic agents
  • Antiproliferative activity
  • Diaryl ether
  • Tubulin polymerization

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