Abstract
Lipase-catalyzed enantioselective transesterification has been performed to obtain chiral halogenated phenyl 2-hydroxypropanones, key intermediates of pharmaceuticals. Effects of organic solvents, reaction temperature, and substrate concentration were also investigated in Novozym 435-catalyzed transesterification of 1-(2,4-difluorophenyl)-2-hydroxypropanone with vinyl butanoate. Optically pure halogenated phenyl 2-hydroxypropanones and their esters have been successfully prepared in good yields (>40%) and excellent enantiopurities (>99%) by Novozym 435-catalyzed transesterification at 30 °C in hexane.
Original language | English |
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Pages (from-to) | 38-41 |
Number of pages | 4 |
Journal | Journal of Molecular Catalysis - B Enzymatic |
Volume | 48 |
Issue number | 1-2 |
DOIs | |
State | Published - 3 Sep 2007 |
Keywords
- Halogenated phenyl 2-hydroxypropanones
- Kinetic resolution
- Lipase
- Novozym 435
- Transesterification