Abstract
Shifting around: A rapid one-pot preparation of a backbone cyclic peptide from peptidyl-tRNA, which has been ejected from the ribosome is described. A series of intramolecular rearrangements release tRNA and afford 1. A cyclization gives 2 and on enzymatic removal of the formylated methionine (fM) the backbone cyclic peptide is generated.
Original language | English |
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Pages (from-to) | 2159-2161 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 9 |
DOIs | |
State | Published - 25 Feb 2011 |
Keywords
- amino acids
- cyclization
- peptide ligation
- peptides
- tRNA