Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off

Taek Jin Kang, Yuuki Hayashi, Hiroaki Suga

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Shifting around: A rapid one-pot preparation of a backbone cyclic peptide from peptidyl-tRNA, which has been ejected from the ribosome is described. A series of intramolecular rearrangements release tRNA and afford 1. A cyclization gives 2 and on enzymatic removal of the formylated methionine (fM) the backbone cyclic peptide is generated.

Original languageEnglish
Pages (from-to)2159-2161
Number of pages3
JournalAngewandte Chemie - International Edition
Volume50
Issue number9
DOIs
StatePublished - 25 Feb 2011

Keywords

  • amino acids
  • cyclization
  • peptide ligation
  • peptides
  • tRNA

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