Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off

Taek Jin Kang; Yuuki Hayashi; Hiroaki Suga

doi:10.1002/anie.201006963

Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off

Taek Jin Kang
, Yuuki Hayashi
, Hiroaki Suga

Department of Chemical and Biochemical Engineering

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Shifting around: A rapid one-pot preparation of a backbone cyclic peptide from peptidyl-tRNA, which has been ejected from the ribosome is described. A series of intramolecular rearrangements release tRNA and afford 1. A cyclization gives 2 and on enzymatic removal of the formylated methionine (fM) the backbone cyclic peptide is generated.

Original language	English
Pages (from-to)	2159-2161
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	9
DOIs	https://doi.org/10.1002/anie.201006963
State	Published - 25 Feb 2011

Keywords

amino acids
cyclization
peptide ligation
peptides
tRNA

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10.1002/anie.201006963

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title = "Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off",

abstract = "Shifting around: A rapid one-pot preparation of a backbone cyclic peptide from peptidyl-tRNA, which has been ejected from the ribosome is described. A series of intramolecular rearrangements release tRNA and afford 1. A cyclization gives 2 and on enzymatic removal of the formylated methionine (fM) the backbone cyclic peptide is generated.",

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AU - Kang, Taek Jin

AU - Hayashi, Yuuki

AU - Suga, Hiroaki

PY - 2011/2/25

Y1 - 2011/2/25

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AB - Shifting around: A rapid one-pot preparation of a backbone cyclic peptide from peptidyl-tRNA, which has been ejected from the ribosome is described. A series of intramolecular rearrangements release tRNA and afford 1. A cyclization gives 2 and on enzymatic removal of the formylated methionine (fM) the backbone cyclic peptide is generated.

KW - amino acids

KW - cyclization

KW - peptide ligation

KW - peptides

KW - tRNA

UR - https://www.scopus.com/pages/publications/79951917745

U2 - 10.1002/anie.201006963

DO - 10.1002/anie.201006963

M3 - Article

C2 - 21344575

AN - SCOPUS:79951917745

SN - 1433-7851

VL - 50

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EP - 2161

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 9

ER -

Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off

Abstract

Keywords

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