Abstract
An efficient tandem route to obtain tetrasubstituted NH pyrroles in a one-pot manner has been developed, staring from simple nitriles, ethyl bromoacetates, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of β-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles in yields up to 91%.
| Original language | English |
|---|---|
| Pages (from-to) | 3336-3340 |
| Number of pages | 5 |
| Journal | Chemistry - An Asian Journal |
| Volume | 16 |
| Issue number | 21 |
| DOIs | |
| State | Published - 2 Nov 2021 |
Keywords
- Blaise reaction
- nitriles
- oxidative dimerization
- tandem reaction
- tetrasubstituted pyrroles
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