TY - JOUR
T1 - Targeting inflammation by flavonoids
T2 - Novel therapeutic strategy for metabolic disorders
AU - Farzaei, Mohammad Hosein
AU - Singh, Amit Kumar
AU - Kumar, Ramesh
AU - Croley, Courtney R.
AU - Pandey, Abhay K.
AU - Coy-Barrera, Ericsson
AU - Patra, Jayanta Kumar
AU - Das, Gitishree
AU - Kerry, Rout George
AU - Annunziata, Giuseppe
AU - Tenore, Gian Carlo
AU - Khan, Haroon
AU - Micucci, Matteo
AU - Budriesi, Roberta
AU - Momtaz, Saeideh
AU - Nabavi, Seyed Mohammad
AU - Bishayee, Anupam
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - A balanced metabolic profile is essential for normal human physiological activities. Disproportions in nutrition give rise to imbalances in metabolism that are associated with aberrant immune function and an elevated risk for inflammatory-associated disorders. Inflammation is a complex process, and numerous mediators affect inflammation-mediated disorders. The available clinical modalities do not effectively address the underlying diseases but rather relieve the symptoms. Therefore, novel targeted agents have the potential to normalize the metabolic system and, thus, provide meaningful therapy to the underlying disorder. In this connection, polyphenols, the well-known and extensively studied phytochemical moieties, were evaluated for their effective role in the restoration of metabolism via various mechanistic signaling pathways. The various flavonoids that we observed in this comprehensive review interfere with the metabolic events that induce inflammation. The mechanisms via which the polyphenols, in particular flavonoids, act provide a promising treatment option for inflammatory disorders. However, detailed clinical studies of such molecules are required to decide their clinical fate.
AB - A balanced metabolic profile is essential for normal human physiological activities. Disproportions in nutrition give rise to imbalances in metabolism that are associated with aberrant immune function and an elevated risk for inflammatory-associated disorders. Inflammation is a complex process, and numerous mediators affect inflammation-mediated disorders. The available clinical modalities do not effectively address the underlying diseases but rather relieve the symptoms. Therefore, novel targeted agents have the potential to normalize the metabolic system and, thus, provide meaningful therapy to the underlying disorder. In this connection, polyphenols, the well-known and extensively studied phytochemical moieties, were evaluated for their effective role in the restoration of metabolism via various mechanistic signaling pathways. The various flavonoids that we observed in this comprehensive review interfere with the metabolic events that induce inflammation. The mechanisms via which the polyphenols, in particular flavonoids, act provide a promising treatment option for inflammatory disorders. However, detailed clinical studies of such molecules are required to decide their clinical fate.
UR - http://www.scopus.com/inward/record.url?scp=85073122306&partnerID=8YFLogxK
U2 - 10.3390/ijms20194957
DO - 10.3390/ijms20194957
M3 - Review article
C2 - 31597283
AN - SCOPUS:85073122306
SN - 1661-6596
VL - 20
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 19
M1 - 4957
ER -
