The 5-HT2 receptor profiles of antipsychotics in the pathogenesis of obsessive-compulsive symptoms in schizophrenia

Sung Wan Kim, Il Seon Shin, Jae Min Kim, Tak Youn, Su Jin Yang, Michael Y. Hwang, Jin Sang Yoon

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Atypical antipsychotics have been reported to induce or exacerbate obsessive-compulsive symptoms (OCS) in patients with schizophrenia. We report the development of de novo obsession induced by sequential treatment with risperidone, aripiprazole, and ziprasidone, which have an antagonist effect on serotonin 5-HT2A receptors in a patient with schizophrenia. The obsession was repeatedly improved after switching the atypical antipsychotics to amisulpride, a selective D2 and D3 receptor antagonist. To our knowledge, this is the first report about ziprasidone-induced OCS in a patient with schizophrenia. In conclusion, this case supports the hypothesis that the antagonist effect on 5-HT2 receptors may be related to atypical antipsychotic-induced OCS.

Original languageEnglish
Pages (from-to)224-226
Number of pages3
JournalClinical Neuropharmacology
Volume32
Issue number4
DOIs
StatePublished - Jul 2009

Keywords

  • Amisulpride
  • Aripiprazole
  • Obsessive-compulsive symptoms
  • Risperidone
  • Schizophrenia
  • Ziprasidone

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