The association between oxidative balance score and lung function: A nationwide cross-sectional survey

Purpose: Given the impact of oxidative imbalance on the development of airway pathologies, this study was undertaken to investigate the association between oxidative balance (OB) scores and lung function in the adult Korean population. Methods: Data of 17,368 adults with available OB scores and pulmonary function test results were extracted from the 2013–2019 Korean National Health and Nutrition Examination Surveys. Multivariable logistic regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for reduced forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) per 1-point decrease in OB score. Dose dependent association of reduced lung function with OB scores was also investigated. Results: Males, low-income subjects, individuals with comorbidities, and those with reduced pulmonary function had lower OB scores (representing oxidative balance). Overall, the association between oxidative imbalance and reduced lung function was remarkable in FVC than FEV₁ (OR [95% CI], 1.06 [1.04–1.07] vs. 1.03 [1.02–1.04]; both p < 0.001). Linear relationships between the level of reduced lung function and OB scores were significantly noted (p for trend<0.001 in both FEV₁ and FVC). Conclusion: Our findings suggest that oxidative imbalance is associated with reduced pulmonary function.