TY - JOUR
T1 - The association of obstructive sleep apnea with dyslipidemia in Korean children and adolescents
T2 - A single-center, cross-sectional study
AU - Kang, Eun Kyeong
AU - Jang, Min Jeong
AU - Kim, Ki Duk
AU - Ahn, Young Min
N1 - Publisher Copyright:
© 2021 American Academy of Sleep Medicine.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Study Objectives: To evaluate whether obstructive sleep apnea (OSA) and its severity are related to dyslipidemia and alanine transaminase elevation as a marker of nonalcoholic fatty liver disease in children. Methods: The data collected frompolysomnography, laboratory measurements (lipid profile and liver enzyme), and bodymass index in children aged 0-18 years who visited the pediatric department between 2012 and 2018 were retrospectively analyzed. Results: There were a total of 273 participants in the study (ages 0-6 years, 7-12 years, and 13-18 years: 61.9%, 26.4%, and 11.7%, respectively). In the ages 7-12 and 13-18 years groups, obesity was strongly associated with OSA severity (Cramer's V = 0.498, P < .001). High-density lipoprotein cholesterol levels were significantly lower in the OSA group than in the non-OSA group, irrespective of the presence of obesity. In addition, high-density lipoprotein cholesterol levels were significantly different between the OSA severity groups after adjusting for body mass index (P = .000). In participants who were obese, moderate and severe OSA were associated with alanine transaminase elevation (P = .023 and P = .045, respectively). Conclusions: This study suggests that OSA may be an independent risk factor for dyslipidemia and that OSA and obesity have a synergistic effect on alanine transaminase elevation. Early diagnosis and treatment of OSA from childhood, especially in obese children, will reduce metabolic complications.
AB - Study Objectives: To evaluate whether obstructive sleep apnea (OSA) and its severity are related to dyslipidemia and alanine transaminase elevation as a marker of nonalcoholic fatty liver disease in children. Methods: The data collected frompolysomnography, laboratory measurements (lipid profile and liver enzyme), and bodymass index in children aged 0-18 years who visited the pediatric department between 2012 and 2018 were retrospectively analyzed. Results: There were a total of 273 participants in the study (ages 0-6 years, 7-12 years, and 13-18 years: 61.9%, 26.4%, and 11.7%, respectively). In the ages 7-12 and 13-18 years groups, obesity was strongly associated with OSA severity (Cramer's V = 0.498, P < .001). High-density lipoprotein cholesterol levels were significantly lower in the OSA group than in the non-OSA group, irrespective of the presence of obesity. In addition, high-density lipoprotein cholesterol levels were significantly different between the OSA severity groups after adjusting for body mass index (P = .000). In participants who were obese, moderate and severe OSA were associated with alanine transaminase elevation (P = .023 and P = .045, respectively). Conclusions: This study suggests that OSA may be an independent risk factor for dyslipidemia and that OSA and obesity have a synergistic effect on alanine transaminase elevation. Early diagnosis and treatment of OSA from childhood, especially in obese children, will reduce metabolic complications.
KW - Children
KW - Dyslipidemia
KW - Nonalcoholic fatty liver disease
KW - Obesity
KW - Obstructive sleep apnea
UR - http://www.scopus.com/inward/record.url?scp=85111772426&partnerID=8YFLogxK
U2 - 10.5664/jcsm.9258
DO - 10.5664/jcsm.9258
M3 - Review article
C2 - 33739258
AN - SCOPUS:85111772426
SN - 1550-9389
VL - 17
SP - 1599
EP - 1605
JO - Journal of Clinical Sleep Medicine
JF - Journal of Clinical Sleep Medicine
IS - 8
ER -