The crystal structure of a natural DNA polymerase complexed with mirror DNA

Jinsu An, Jaewoo Choi, Dohyeon Hwang, Jihyun Park, Charles W. Pemble, Thi Hoai Men Duong, Kyoung Ran Kim, Heechul Ahn, Hak Suk Chung, Dae Ro Ahn

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.

Original languageEnglish
Pages (from-to)2186-2189
Number of pages4
JournalChemical Communications
Volume56
Issue number14
DOIs
StatePublished - 18 Feb 2020

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