The crystal structure of a natural DNA polymerase complexed with mirror DNA

  • Jinsu An
  • , Jaewoo Choi
  • , Dohyeon Hwang
  • , Jihyun Park
  • , Charles W. Pemble
  • , Thi Hoai Men Duong
  • , Kyoung Ran Kim
  • , Heechul Ahn
  • , Hak Suk Chung
  • , Dae Ro Ahn

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.

Original languageEnglish
Pages (from-to)2186-2189
Number of pages4
JournalChemical Communications
Volume56
Issue number14
DOIs
StatePublished - 18 Feb 2020

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