The crystal structure of a natural DNA polymerase complexed with mirror DNA

Jinsu An; Jaewoo Choi; Dohyeon Hwang; Jihyun Park; Charles W. Pemble; Thi Hoai Men Duong; Kyoung Ran Kim; Heechul Ahn; Hak Suk Chung; Dae Ro Ahn

doi:10.1039/c9cc09351f

The crystal structure of a natural DNA polymerase complexed with mirror DNA

Jinsu An
, Jaewoo Choi
, Dohyeon Hwang
, Jihyun Park
, Charles W. Pemble
, Thi Hoai Men Duong
, Kyoung Ran Kim
, Heechul Ahn
, Hak Suk Chung
, Dae Ro Ahn

Department of Pharmacy

Korea Institute of Science and Technology
University of Science and Technology UST
Rigaku Corporation
Dongguk University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.

Original language	English
Pages (from-to)	2186-2189
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	14
DOIs	https://doi.org/10.1039/c9cc09351f
State	Published - 18 Feb 2020

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10.1039/c9cc09351f

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title = "The crystal structure of a natural DNA polymerase complexed with mirror DNA",

abstract = "The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.",

author = "Jinsu An and Jaewoo Choi and Dohyeon Hwang and Jihyun Park and Pemble, \{Charles W.\} and Duong, \{Thi Hoai Men\} and Kim, \{Kyoung Ran\} and Heechul Ahn and Chung, \{Hak Suk\} and Ahn, \{Dae Ro\}",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry.",

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doi = "10.1039/c9cc09351f",

language = "English",

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journal = "Chemical Communications",

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T1 - The crystal structure of a natural DNA polymerase complexed with mirror DNA

AU - An, Jinsu

AU - Choi, Jaewoo

AU - Hwang, Dohyeon

AU - Park, Jihyun

AU - Pemble, Charles W.

AU - Duong, Thi Hoai Men

AU - Kim, Kyoung Ran

AU - Ahn, Heechul

AU - Chung, Hak Suk

AU - Ahn, Dae Ro

PY - 2020/2/18

Y1 - 2020/2/18

N2 - The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.

AB - The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.

UR - https://www.scopus.com/pages/publications/85079679656

U2 - 10.1039/c9cc09351f

DO - 10.1039/c9cc09351f

M3 - Article

C2 - 31971182

AN - SCOPUS:85079679656

SN - 1359-7345

VL - 56

SP - 2186

EP - 2189

JO - Chemical Communications

JF - Chemical Communications

IS - 14

ER -

The crystal structure of a natural DNA polymerase complexed with mirror DNA

Abstract

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