The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells

Sun Woong Kang, Byung Hyun Cha, Honghyun Park, Kwang Sook Park, Kuen Yong Lee, Soo Hong Lee

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin α1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.

Original languageEnglish
Pages (from-to)673-679
Number of pages7
JournalMacromolecular Bioscience
Volume11
Issue number5
DOIs
StatePublished - 12 May 2011

Keywords

  • Adhesion
  • Biological applications of polymers
  • Biomaterials
  • Hydrogels
  • Tissue engineering

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