Abstract
The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin α1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.
Original language | English |
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Pages (from-to) | 673-679 |
Number of pages | 7 |
Journal | Macromolecular Bioscience |
Volume | 11 |
Issue number | 5 |
DOIs | |
State | Published - 12 May 2011 |
Keywords
- Adhesion
- Biological applications of polymers
- Biomaterials
- Hydrogels
- Tissue engineering