The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells

Sun Woong Kang; Byung Hyun Cha; Honghyun Park; Kwang Sook Park; Kuen Yong Lee; Soo Hong Lee

doi:10.1002/mabi.201000479

The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells

Sun Woong Kang
, Byung Hyun Cha
, Honghyun Park
, Kwang Sook Park
, Kuen Yong Lee
, Soo Hong Lee

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin α1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.

Original language	English
Pages (from-to)	673-679
Number of pages	7
Journal	Macromolecular Bioscience
Volume	11
Issue number	5
DOIs	https://doi.org/10.1002/mabi.201000479
State	Published - 12 May 2011

Keywords

Adhesion
Biological applications of polymers
Biomaterials
Hydrogels
Tissue engineering

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10.1002/mabi.201000479

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abstract = "The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin α1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.",

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AU - Cha, Byung Hyun

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AU - Park, Kwang Sook

AU - Lee, Kuen Yong

AU - Lee, Soo Hong

PY - 2011/5/12

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N2 - The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin α1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.

AB - The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin α1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.

KW - Adhesion

KW - Biological applications of polymers

KW - Biomaterials

KW - Hydrogels

KW - Tissue engineering

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The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells

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Keywords

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