TY - JOUR
T1 - The effects of 1064 nm Nd:YAG laser irradiation under the different treatment conditions for skin rejuvenation
T2 - Quantitative and histologic analyses
AU - Park, So Ra
AU - Lee, Ju Hwan
AU - Jo, Jeong Ho
AU - Seo, Young Kwon
AU - Kim, Sung Min
PY - 2013
Y1 - 2013
N2 - Objective: The aim of this study was to estimate heat distributions and evaluate degrees of tissue damages histologically after transmitting therapeutic lasers to find optimum ranges for skin rejuvenation. Background data: To treat skin aging, many researchers attempted to evaluate treatment effects for the different approaches. The noninvasive skin rejuvenation method was mostly employed to optimize the therapeutic effects by quantifying the laser conditions. However, current approaches produced low reliability for predicting tissue damage. Methods: We transmitted the 1064 nm Nd:YAG laser into a skin-mimicking phantom and pig skin samples according to the different fluences and spot diameters, and analyzed its internal-external temperatures. For histologic analyses, we also stained pig skin samples with hematoxylin and eosin (H&E) and compared degrees of tissue damage. The spot diameter conditions were classified into 5, 8, and 10 mm, and the fluence conditions were divided into 26, 30, and 36 J/cm2. In addition, the pulse duration was set to 30 ms. Results: In our experiments, the conditions of a spot diameter of 5 mm with a fluence of 36 J/cm2 and a spot diameter of 10 mm with a fluence of 26 J/cm2 yielded the maximum surface temperatures>40 C. Regarding histologic evaluations, we also found that the degrees of internal thermal injuries are worsened as spot diameters and fluences increased. Conclusions: We selected the optimum treatment conditions for skin rejuvenation as being the laser condition of a spot diameter of 5 mm with a fluence of 36 J/cm2 and a spot diameter of 10 mm with a fluence of 26 J/cm 2.
AB - Objective: The aim of this study was to estimate heat distributions and evaluate degrees of tissue damages histologically after transmitting therapeutic lasers to find optimum ranges for skin rejuvenation. Background data: To treat skin aging, many researchers attempted to evaluate treatment effects for the different approaches. The noninvasive skin rejuvenation method was mostly employed to optimize the therapeutic effects by quantifying the laser conditions. However, current approaches produced low reliability for predicting tissue damage. Methods: We transmitted the 1064 nm Nd:YAG laser into a skin-mimicking phantom and pig skin samples according to the different fluences and spot diameters, and analyzed its internal-external temperatures. For histologic analyses, we also stained pig skin samples with hematoxylin and eosin (H&E) and compared degrees of tissue damage. The spot diameter conditions were classified into 5, 8, and 10 mm, and the fluence conditions were divided into 26, 30, and 36 J/cm2. In addition, the pulse duration was set to 30 ms. Results: In our experiments, the conditions of a spot diameter of 5 mm with a fluence of 36 J/cm2 and a spot diameter of 10 mm with a fluence of 26 J/cm2 yielded the maximum surface temperatures>40 C. Regarding histologic evaluations, we also found that the degrees of internal thermal injuries are worsened as spot diameters and fluences increased. Conclusions: We selected the optimum treatment conditions for skin rejuvenation as being the laser condition of a spot diameter of 5 mm with a fluence of 36 J/cm2 and a spot diameter of 10 mm with a fluence of 26 J/cm 2.
UR - http://www.scopus.com/inward/record.url?scp=84878833171&partnerID=8YFLogxK
U2 - 10.1089/pho.2013.3483
DO - 10.1089/pho.2013.3483
M3 - Article
C2 - 23741996
AN - SCOPUS:84878833171
SN - 1549-5418
VL - 31
SP - 283
EP - 292
JO - Photomedicine and Laser Surgery
JF - Photomedicine and Laser Surgery
IS - 6
ER -