The effects of co-immobilization of epidermal growth factor and adhesion factor on the proliferation of ligament cell

Yong Soon Park, Young Kwon Seo, Hwa Sung Lee, Soon Yong Kwon, Jung Keug Park

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The epidermal growth factor and cell adhesion factor were co-immobilized on a tissue culture plate to allow the proliferation of human ligament cells. The co-immobilized surfaces were prepared by irradiating a photo-reactive polypeptide containing azidophenyl-derivatized side-chains with UV. The immobilized cell adhesion factor induced initial cell adhesion on the surfaces, and the immobilized cell growth factor appeared to induce cell proliferation. The ligament cells proliferated on the EGF-immobilized plate until 10 days post-culture. The co-immobilization of the epidermal growth factor appears to be an effective method for healing an anterior cruciate ligament through the rapid proliferation of ligament cells.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalMacromolecular Symposia
Volume249-250
DOIs
StatePublished - 2007

Keywords

  • Adhesion factor
  • Co-immobilization
  • Epidermal growth factor
  • Ligament
  • Photo-immobilization
  • Proliferation

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