Abstract
Background: Hydrogen sulfide (H2S) produces a protective effect against myocardial ischemia and reperfusion injury. Sevoflurane, which is used for anesthesia in cardiac problem patients, also has a protective effect. This study is designed to reveal the effects of H2S under sevoflurane using rat hearts. Methods: The hearts were Langendorff-perfused, subjected to 30 minutes ischemia and 60 minutes reperfusion. Group I was a control group. The other groups were pretreated for 15 minutes before ischemia as follows: 1.6% sevoflurane for group S; 18.5 μM H2S S for group H; and 1.6 % sevoflurane and 18.5 μM H2S simultaneously for group HS. Hemodynamics and the infarct size were measured. Results: Group HS presented depressed hemodynamics during pretreatment. LV function in group HS achieved better recovery than group I after reperfusion. The infarct size of groups S, H and HS was smaller than group I, while there were no differences between groups S, H and HS. Conclusions: Exogenous H2S did not enhance the preconditioning effects of sevoflurane. Rather, the results suggest that H2S under sevoflurane might depress hemodynamics.
Original language | English |
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Pages (from-to) | 461-467 |
Number of pages | 7 |
Journal | Korean Journal of Anesthesiology |
Volume | 62 |
Issue number | 5 |
DOIs | |
State | Published - May 2012 |
Keywords
- Heart
- Hydrogen sulfide
- In vitro
- Ischemia
- Reperfusion injury
- Sevoflurane