TY - JOUR
T1 - The efficacy and safety of AP-FHG0604T on female pattern hair loss
T2 - A randomized double-blind placebo-controlled clinical trial
AU - Shin, Hyo Seung
AU - Lee, Seung Ho
AU - Kim, Dong Hyun
AU - An, Jee Soo
AU - Kwon, Oh Sang
AU - Eun, Hee Chul
AU - Kim, Kyu Han
PY - 2007/2
Y1 - 2007/2
N2 - Background: Hair loss is a very common disorder and the number of patients is known to be increasing. Female pattern hair loss (FPHL) is not only a medical problem but also a very severe psychosocial problem for many female patients. Anti-androgen drugs, mineral supplements and topical minoxidil have all been used for the treatment of FPHL. However they do not always achieve successful results and there is still much need for more effective therapy. Objective: The purpose of this 18-week, double-blind, placebo-controlled, randomized clinical trial was to investigate the efficacy and safety of a new topical agent, AP-FHG0604T, in the treatment of FPHL. Methods: A total of 33 women with FPHL (mean age: 33.4 years old) applied either a topical AP-FHG0604T solution (n=17), or placebo (vehicle for AP-FHG0604T solution; n=16) twice daily. Efficacy was evaluated by phototrichogram, investigator's photographic and patient's subjective assessments. All adverse effects were reported during the study. Results: After 18 weeks of therapy, topical AP-FHG0604T treatment showed a significant improvement compared to baseline values of total hak count, non-vellus hak count, and linear hak growth rate. In the placebo group, non-vellus hak count and ratio of anagen hak significantly decreased. The change rates of total hak count and non-vellus hak count hi the AP-FHG0604T group were significantly higher than those in the placebo group. Neither investigator's photographic assessments nor patient's subjective assessments of hak growth showed statistically significant differences between the AP-FHG0604T group or the placebo group. Some patients who used APFHG0604T complained of local irritation during the study, but the irritation was so mild that they did not need any treatment for this. Conclusion: We conclude that AP-FHG0604T is a safe and efficient topical agent which can be used as another treatment of choice for FPHL, as shown by objective assessment with phototrichogram.
AB - Background: Hair loss is a very common disorder and the number of patients is known to be increasing. Female pattern hair loss (FPHL) is not only a medical problem but also a very severe psychosocial problem for many female patients. Anti-androgen drugs, mineral supplements and topical minoxidil have all been used for the treatment of FPHL. However they do not always achieve successful results and there is still much need for more effective therapy. Objective: The purpose of this 18-week, double-blind, placebo-controlled, randomized clinical trial was to investigate the efficacy and safety of a new topical agent, AP-FHG0604T, in the treatment of FPHL. Methods: A total of 33 women with FPHL (mean age: 33.4 years old) applied either a topical AP-FHG0604T solution (n=17), or placebo (vehicle for AP-FHG0604T solution; n=16) twice daily. Efficacy was evaluated by phototrichogram, investigator's photographic and patient's subjective assessments. All adverse effects were reported during the study. Results: After 18 weeks of therapy, topical AP-FHG0604T treatment showed a significant improvement compared to baseline values of total hak count, non-vellus hak count, and linear hak growth rate. In the placebo group, non-vellus hak count and ratio of anagen hak significantly decreased. The change rates of total hak count and non-vellus hak count hi the AP-FHG0604T group were significantly higher than those in the placebo group. Neither investigator's photographic assessments nor patient's subjective assessments of hak growth showed statistically significant differences between the AP-FHG0604T group or the placebo group. Some patients who used APFHG0604T complained of local irritation during the study, but the irritation was so mild that they did not need any treatment for this. Conclusion: We conclude that AP-FHG0604T is a safe and efficient topical agent which can be used as another treatment of choice for FPHL, as shown by objective assessment with phototrichogram.
KW - AP-FHG0604T
KW - Female pattern hair loss
KW - Phototrichogram
UR - http://www.scopus.com/inward/record.url?scp=34249710839&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:34249710839
SN - 0494-4739
VL - 45
SP - 119
EP - 126
JO - Korean Journal of Dermatology
JF - Korean Journal of Dermatology
IS - 2
ER -