TY - JOUR
T1 - The longitudinal effects of chronotype on chemotherapy-induced nausea and vomiting in patients with breast cancer receiving neoadjuvant chemotherapy
AU - Jung, Sanghyup
AU - Son, Kyung Lak
AU - Jung, Saim
AU - Moon, Jung Yoon
AU - Oh, Gyu Han
AU - Yeom, Chan Woo
AU - Lee, Kwang Min
AU - Kim, Won Hyoung
AU - Jung, Dooyoung
AU - Kim, Tae Yong
AU - Im, Seock Ah
AU - Lee, Kyung Hun
AU - Spiegel, David
AU - Hahm, Bong Jin
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/6
Y1 - 2022/6
N2 - Objective: The object of this longitudinal cohort study was to investigate whether chronotype affects the incidence of chemotherapy-induced nausea and vomiting (CINV) among patients with breast cancer. Methods: The study included a total of 203 breast cancer patients who received neoadjuvant chemotherapy using a regimen of doxorubicin and cyclophosphamide with high emetogenicity. Patients received four cycles of chemotherapy in approximately three months. Patients completed questionnaires including the Munich Chronotype Questionnaire (MCTQ) before the first chemotherapy and the Multinational Association of Supportive Care in Cancer Antiemesis Tool (MAT) after each of the four chemotherapy sessions. To confirm the effect of chronotype on CINV during the four cycles, we performed statistical analyses using a generalized estimating equation (GEE). Results: CINV occurred in 108 (53.2%), 112 (55.2%), 102 (50.3%), and 62 (30.5%) patients during four cycles of treatment. In the GEE approach, late and early chronotypes (vs. intermediate chronotype) were associated with an increased risk of CINV (late chronotype: odds ratio [OR], 2.06; 95% confidence interval [CI], 1.41–2.99; p < 0.001, early chronotype: OR, 1.84; CI, 1.25–2.73; p = 0.002), which remained significant even after adjusting for age, BMI, antiemetic treatment, history of nausea and vomiting, anxiety, and sleep quality. Conclusion: Chronotype affected CINV across the four cycles of neoadjuvant chemotherapy in patients with breast cancer, suggesting the need to consider chronotype in predicting and managing CINV.
AB - Objective: The object of this longitudinal cohort study was to investigate whether chronotype affects the incidence of chemotherapy-induced nausea and vomiting (CINV) among patients with breast cancer. Methods: The study included a total of 203 breast cancer patients who received neoadjuvant chemotherapy using a regimen of doxorubicin and cyclophosphamide with high emetogenicity. Patients received four cycles of chemotherapy in approximately three months. Patients completed questionnaires including the Munich Chronotype Questionnaire (MCTQ) before the first chemotherapy and the Multinational Association of Supportive Care in Cancer Antiemesis Tool (MAT) after each of the four chemotherapy sessions. To confirm the effect of chronotype on CINV during the four cycles, we performed statistical analyses using a generalized estimating equation (GEE). Results: CINV occurred in 108 (53.2%), 112 (55.2%), 102 (50.3%), and 62 (30.5%) patients during four cycles of treatment. In the GEE approach, late and early chronotypes (vs. intermediate chronotype) were associated with an increased risk of CINV (late chronotype: odds ratio [OR], 2.06; 95% confidence interval [CI], 1.41–2.99; p < 0.001, early chronotype: OR, 1.84; CI, 1.25–2.73; p = 0.002), which remained significant even after adjusting for age, BMI, antiemetic treatment, history of nausea and vomiting, anxiety, and sleep quality. Conclusion: Chronotype affected CINV across the four cycles of neoadjuvant chemotherapy in patients with breast cancer, suggesting the need to consider chronotype in predicting and managing CINV.
KW - Cancer
KW - Chemotherapy side effect
KW - Chemotherapy-induced nausea and vomiting
KW - Chronotype
KW - Neoadjuvant chemotherapy
UR - http://www.scopus.com/inward/record.url?scp=85127354087&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychores.2022.110804
DO - 10.1016/j.jpsychores.2022.110804
M3 - Article
C2 - 35381494
AN - SCOPUS:85127354087
SN - 0022-3999
VL - 157
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
M1 - 110804
ER -