The role of CDK5 in tumours and tumour microenvironments

Phuong Anh Do; Chang Hoon Lee

doi:10.3390/cancers13010101

The role of CDK5 in tumours and tumour microenvironments

Phuong Anh Do
, Chang Hoon Lee

Dongguk University

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Cyclin-dependent kinase 5 (CDK5), which belongs to the protein kinase family, regulates neuronal function but is also associated with cancer development and has been proposed as a target for cancer treatment. Indeed, CDK5 has roles in cell proliferation, apoptosis, angiogenesis, inflamma-tion, and immune response. Aberrant CDK5 activation triggers tumour progression in numerous types of cancer. In this review, we summarise the role of CDK5 in cancer and neurons and CDK5 inhibitors. We expect that our review helps researchers to develop CDK5 inhibitors as treatments for refractory cancer.

Original language	English
Article number	101
Pages (from-to)	1-27
Number of pages	27
Journal	Cancers
Volume	13
Issue number	1
DOIs	https://doi.org/10.3390/cancers13010101
State	Published - Dec 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CDK5
Cancer
Microtubule
Neuron
Tumour microenvironments

Access to Document

10.3390/cancers13010101

Cite this

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title = "The role of CDK5 in tumours and tumour microenvironments",

abstract = "Cyclin-dependent kinase 5 (CDK5), which belongs to the protein kinase family, regulates neuronal function but is also associated with cancer development and has been proposed as a target for cancer treatment. Indeed, CDK5 has roles in cell proliferation, apoptosis, angiogenesis, inflamma-tion, and immune response. Aberrant CDK5 activation triggers tumour progression in numerous types of cancer. In this review, we summarise the role of CDK5 in cancer and neurons and CDK5 inhibitors. We expect that our review helps researchers to develop CDK5 inhibitors as treatments for refractory cancer.",

keywords = "CDK5, Cancer, Microtubule, Neuron, Tumour microenvironments",

author = "Do, \{Phuong Anh\} and Lee, \{Chang Hoon\}",

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year = "2021",

month = dec,

doi = "10.3390/cancers13010101",

language = "English",

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AU - Lee, Chang Hoon

PY - 2021/12

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N2 - Cyclin-dependent kinase 5 (CDK5), which belongs to the protein kinase family, regulates neuronal function but is also associated with cancer development and has been proposed as a target for cancer treatment. Indeed, CDK5 has roles in cell proliferation, apoptosis, angiogenesis, inflamma-tion, and immune response. Aberrant CDK5 activation triggers tumour progression in numerous types of cancer. In this review, we summarise the role of CDK5 in cancer and neurons and CDK5 inhibitors. We expect that our review helps researchers to develop CDK5 inhibitors as treatments for refractory cancer.

AB - Cyclin-dependent kinase 5 (CDK5), which belongs to the protein kinase family, regulates neuronal function but is also associated with cancer development and has been proposed as a target for cancer treatment. Indeed, CDK5 has roles in cell proliferation, apoptosis, angiogenesis, inflamma-tion, and immune response. Aberrant CDK5 activation triggers tumour progression in numerous types of cancer. In this review, we summarise the role of CDK5 in cancer and neurons and CDK5 inhibitors. We expect that our review helps researchers to develop CDK5 inhibitors as treatments for refractory cancer.

KW - CDK5

KW - Cancer

KW - Microtubule

KW - Neuron

KW - Tumour microenvironments

UR - https://www.scopus.com/pages/publications/85098879933

U2 - 10.3390/cancers13010101

DO - 10.3390/cancers13010101

M3 - Review article

AN - SCOPUS:85098879933

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VL - 13

SP - 1

EP - 27

JO - Cancers

JF - Cancers

IS - 1

M1 - 101

ER -

The role of CDK5 in tumours and tumour microenvironments

Abstract

UN SDGs

Keywords

Access to Document

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