The role of microbiome in colorectal carcinogenesis and its clinical potential as a target for cancer treatment

Sang Hoon Kim, Yun Jeong Lim

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The role of gut microbiome-intestinal immune complex in the development of colorectal cancer and its progression is well recognized. Accordingly, certain microbial strains tend to colonize or vanish in patients with colorectal cancer. Probiotics, prebiotics, and synbiotics are expected to exhibit both anti-tumor effects and chemopreventive effects during cancer treatment through mechanisms such as xenometabolism, immune interactions, and altered eco-community. Microbial modulation can also be safely used to prevent complications during peri-operational periods of colorectal surgery. A deeper understanding of the role of intestinal microbiota as a target for colorectal cancer treatment will lead the way to a better prognosis for colorectal cancer patients.

Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalIntestinal Research
Volume20
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Colon neoplasms
  • Intestinal microbiome
  • Prebiotics
  • Probiotics
  • Synbiotics

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