The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy

Eluri Pavitra; Jyothsna Kancharla; Vivek Kumar Gupta; Kiran Prasad; Ju Yong Sung; Jigyeong Kim; Mandava Bhuvan Tej; Rino Choi; Jeong Hwan Lee; Young Kyu Han; Ganji Seeta Rama Raju; L. V.K.S. Bhaskar; Yun Suk Huh

doi:10.1016/j.biopha.2023.114822

The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy

Eluri Pavitra, Jyothsna Kancharla, Vivek Kumar Gupta, Kiran Prasad, Ju Yong Sung, Jigyeong Kim, Mandava Bhuvan Tej, Rino Choi, Jeong Hwan Lee, Young Kyu Han, Ganji Seeta Rama Raju, L. V.K.S. Bhaskar, Yun Suk Huh

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Abstract

Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB.

Original language	English
Article number	114822
Journal	Biomedicine and Pharmacotherapy
Volume	163
DOIs	https://doi.org/10.1016/j.biopha.2023.114822
State	Published - Jul 2023

Keywords

Angiogenesis
Apoptosis
Breast cancer
Chemoresistance
Metastasis
NF-κB

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biopha.2023.114822

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Pavitra, E., Kancharla, J., Gupta, V. K., Prasad, K., Sung, J. Y., Kim, J., Tej, M. B., Choi, R., Lee, J. H., Han, Y. K., Raju, G. S. R., Bhaskar, L. V. K. S., & Huh, Y. S. (2023). The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy. Biomedicine and Pharmacotherapy, 163, Article 114822. https://doi.org/10.1016/j.biopha.2023.114822

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title = "The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy",

abstract = "Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB.",

keywords = "Angiogenesis, Apoptosis, Breast cancer, Chemoresistance, Metastasis, NF-κB",

author = "Eluri Pavitra and Jyothsna Kancharla and Gupta, {Vivek Kumar} and Kiran Prasad and Sung, {Ju Yong} and Jigyeong Kim and Tej, {Mandava Bhuvan} and Rino Choi and Lee, {Jeong Hwan} and Han, {Young Kyu} and Raju, {Ganji Seeta Rama} and Bhaskar, {L. V.K.S.} and Huh, {Yun Suk}",

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doi = "10.1016/j.biopha.2023.114822",

language = "English",

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AU - Pavitra, Eluri

AU - Kancharla, Jyothsna

AU - Gupta, Vivek Kumar

AU - Prasad, Kiran

AU - Sung, Ju Yong

AU - Kim, Jigyeong

AU - Tej, Mandava Bhuvan

AU - Choi, Rino

AU - Lee, Jeong Hwan

AU - Han, Young Kyu

AU - Raju, Ganji Seeta Rama

AU - Bhaskar, L. V.K.S.

AU - Huh, Yun Suk

PY - 2023/7

Y1 - 2023/7

N2 - Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB.

AB - Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB.

KW - Angiogenesis

KW - Apoptosis

KW - Breast cancer

KW - Chemoresistance

KW - Metastasis

KW - NF-κB

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U2 - 10.1016/j.biopha.2023.114822

DO - 10.1016/j.biopha.2023.114822

M3 - Review article

C2 - 37146418

AN - SCOPUS:85154050639

SN - 0753-3322

VL - 163

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

M1 - 114822

ER -

The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy

Abstract

Keywords

UN SDGs

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