TY - JOUR
T1 - The role of TRP channels in allergic inflammation and its clinical relevance
AU - Nam, Joo Hyun
AU - Kim, Woo Kyung
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Allergy refers to an abnormal adaptive immune response to non-infectious environmental substances (allergen) that can induce various diseases such as asthma, atopic der-matitis, and allergic rhinitis. In this allergic inflammation, various immune cells, such as B cells, T cells, and mast cells, are involved and undergo complex interactions that cause a vari-ety of pathophysiological conditions. In immune cells, calcium ions play a crucial role in controlling intracellular Ca2+ signaling pathways. Cations, such as Na+, indirectly modulate the calcium signal generation by regulating cell membrane potential. This intracellular Ca2+ signaling is mediated by various cation channels; among them, the Transient Receptor Potential (TRP) family is present in almost all immune cell types, and each channel has a unique function in regulating Ca2+ signals. In this review, we focus on the role of TRP ion channels in allergic inflammatory responses in T cells and mast cells. In addition, the TRP ion channels, which are attracting attention in clinical practice in relation to allergic diseases, and the current status of the development of therapeutic agents that target TRP channels are dis-cussed.
AB - Allergy refers to an abnormal adaptive immune response to non-infectious environmental substances (allergen) that can induce various diseases such as asthma, atopic der-matitis, and allergic rhinitis. In this allergic inflammation, various immune cells, such as B cells, T cells, and mast cells, are involved and undergo complex interactions that cause a vari-ety of pathophysiological conditions. In immune cells, calcium ions play a crucial role in controlling intracellular Ca2+ signaling pathways. Cations, such as Na+, indirectly modulate the calcium signal generation by regulating cell membrane potential. This intracellular Ca2+ signaling is mediated by various cation channels; among them, the Transient Receptor Potential (TRP) family is present in almost all immune cell types, and each channel has a unique function in regulating Ca2+ signals. In this review, we focus on the role of TRP ion channels in allergic inflammatory responses in T cells and mast cells. In addition, the TRP ion channels, which are attracting attention in clinical practice in relation to allergic diseases, and the current status of the development of therapeutic agents that target TRP channels are dis-cussed.
KW - Allergic rhinitis
KW - Asthma
KW - Atopic dermatitis
KW - Calcium signaling
KW - Mast cells
KW - T cells
KW - TRP channels
UR - http://www.scopus.com/inward/record.url?scp=85082653092&partnerID=8YFLogxK
U2 - 10.2174/0929867326666181126113015
DO - 10.2174/0929867326666181126113015
M3 - Review article
C2 - 30474526
AN - SCOPUS:85082653092
SN - 0929-8673
VL - 27
SP - 1446
EP - 1468
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 9
ER -