Therapeutic effects of specialized pro-resolving lipids mediators on cardiac fibrosis via nrf2 activation

Gyeoung Jin Kang, Eun Ji Kim, Chang Hoon Lee

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis. In order to control such oxidative stress, the importance of nuclear factor erythropoietin 2 related factor 2 (NRF2) has recently been highlighted. In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Additionally, we will discuss their effects on cardiac fibrosis via NRF2 activation.

Original languageEnglish
Article number1259
Pages (from-to)1-27
Number of pages27
JournalAntioxidants
Volume9
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Cardiac fibrosis
  • Lipoxins
  • Maresins
  • Neuroprotectins
  • NRF2
  • Resolvins

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