Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model

Inho Baek; Alvin Bacero Bello; Jieun Jeon; Yoshie Arai; Byung Hyun Cha; Byoung Ju Kim; Soo Hong Lee

doi:10.1177/20417314221116754

Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model

Inho Baek, Alvin Bacero Bello, Jieun Jeon, Yoshie Arai, Byung Hyun Cha, Byoung Ju Kim, Soo Hong Lee

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Bone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through endochondral ossification has been reported. Our study compared EGPCs with bone marrow-derived mesenchymal stem cells (BM-MSCs) and suggested the therapeutic potential of new bone regeneration. In this study, we analyzed the characteristics between EGPCs and BM-MSCs based on morphological characteristics and molecular profiles. EGPCs expressed chondrogenic and osteogenic markers higher than BM-MSCs. Additionally, in co-culture with BM-MSCs, EGPCs induced an increase in chondrogenic, osteogenic, and hypertrophic markers of BM-MSCs. Finally, EGPCs induced higher bone regeneration than BM-MSCs in the osteoporosis model. Overall, we suggest the possibility of EGPCs as cell therapy for effective bone regeneration.

Original language	English
Journal	Journal of Tissue Engineering
Volume	13
DOIs	https://doi.org/10.1177/20417314221116754
State	Published - 2022

Keywords

bone regeneration
endochondral ossification
Epiphyseal plate
growth plate cells
osteoporosis

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title = "Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model",

abstract = "Bone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through endochondral ossification has been reported. Our study compared EGPCs with bone marrow-derived mesenchymal stem cells (BM-MSCs) and suggested the therapeutic potential of new bone regeneration. In this study, we analyzed the characteristics between EGPCs and BM-MSCs based on morphological characteristics and molecular profiles. EGPCs expressed chondrogenic and osteogenic markers higher than BM-MSCs. Additionally, in co-culture with BM-MSCs, EGPCs induced an increase in chondrogenic, osteogenic, and hypertrophic markers of BM-MSCs. Finally, EGPCs induced higher bone regeneration than BM-MSCs in the osteoporosis model. Overall, we suggest the possibility of EGPCs as cell therapy for effective bone regeneration.",

keywords = "bone regeneration, endochondral ossification, Epiphyseal plate, growth plate cells, osteoporosis",

author = "Inho Baek and Bello, {Alvin Bacero} and Jieun Jeon and Yoshie Arai and Cha, {Byung Hyun} and Kim, {Byoung Ju} and Lee, {Soo Hong}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2022",

doi = "10.1177/20417314221116754",

language = "English",

volume = "13",

journal = "Journal of Tissue Engineering",

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T1 - Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model

AU - Baek, Inho

AU - Bello, Alvin Bacero

AU - Jeon, Jieun

AU - Arai, Yoshie

AU - Cha, Byung Hyun

AU - Kim, Byoung Ju

AU - Lee, Soo Hong

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022

Y1 - 2022

N2 - Bone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through endochondral ossification has been reported. Our study compared EGPCs with bone marrow-derived mesenchymal stem cells (BM-MSCs) and suggested the therapeutic potential of new bone regeneration. In this study, we analyzed the characteristics between EGPCs and BM-MSCs based on morphological characteristics and molecular profiles. EGPCs expressed chondrogenic and osteogenic markers higher than BM-MSCs. Additionally, in co-culture with BM-MSCs, EGPCs induced an increase in chondrogenic, osteogenic, and hypertrophic markers of BM-MSCs. Finally, EGPCs induced higher bone regeneration than BM-MSCs in the osteoporosis model. Overall, we suggest the possibility of EGPCs as cell therapy for effective bone regeneration.

AB - Bone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through endochondral ossification has been reported. Our study compared EGPCs with bone marrow-derived mesenchymal stem cells (BM-MSCs) and suggested the therapeutic potential of new bone regeneration. In this study, we analyzed the characteristics between EGPCs and BM-MSCs based on morphological characteristics and molecular profiles. EGPCs expressed chondrogenic and osteogenic markers higher than BM-MSCs. Additionally, in co-culture with BM-MSCs, EGPCs induced an increase in chondrogenic, osteogenic, and hypertrophic markers of BM-MSCs. Finally, EGPCs induced higher bone regeneration than BM-MSCs in the osteoporosis model. Overall, we suggest the possibility of EGPCs as cell therapy for effective bone regeneration.

KW - bone regeneration

KW - endochondral ossification

KW - Epiphyseal plate

KW - growth plate cells

KW - osteoporosis

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U2 - 10.1177/20417314221116754

DO - 10.1177/20417314221116754

M3 - Article

AN - SCOPUS:85136173597

SN - 2041-7314

VL - 13

JO - Journal of Tissue Engineering

JF - Journal of Tissue Engineering

ER -

Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model

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Keywords

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