TY - JOUR
T1 - Thiazolidinediones as a novel class of algicides against red tide harmful algal species
AU - Kim, Yeon Mi
AU - Wu, Ying
AU - Duong, Thi Uyen
AU - Ghodake, Gajanan S.
AU - Kim, Si Wouk
AU - Jin, Eonseon
AU - Cho, Hoon
PY - 2010/12
Y1 - 2010/12
N2 - This paper reports the synthesis of 28 thiazolidinedione derivatives along with their algicidal activity against microalgae causing harmful algal blooming. Among the 28 compounds tested, most showed effective algicidal activity against Heterosigma akashiwo, Chattonella marina, and Cochlodinium polykrikoides, while non-harmful algae were relatively tolerant to these thiazolidinedione derivatives. Compounds 6, 13, and 22 were the most potent against C. polykrikoides with IC50 values <0.5 μM. Among the thiazolidinedione derivatives tested, compounds 7, 13, 27, and 28 were extremely competent and selective to C. polykrikoides with IC50 values ranging from 0.1 to 2 μM, while C. marina and H. akashiwo showed an IC50 value ranging from 30 to 130 μM. These results show that some thiazolidinedione derivatives can act as potent algicides against harmful algal blooms.
AB - This paper reports the synthesis of 28 thiazolidinedione derivatives along with their algicidal activity against microalgae causing harmful algal blooming. Among the 28 compounds tested, most showed effective algicidal activity against Heterosigma akashiwo, Chattonella marina, and Cochlodinium polykrikoides, while non-harmful algae were relatively tolerant to these thiazolidinedione derivatives. Compounds 6, 13, and 22 were the most potent against C. polykrikoides with IC50 values <0.5 μM. Among the thiazolidinedione derivatives tested, compounds 7, 13, 27, and 28 were extremely competent and selective to C. polykrikoides with IC50 values ranging from 0.1 to 2 μM, while C. marina and H. akashiwo showed an IC50 value ranging from 30 to 130 μM. These results show that some thiazolidinedione derivatives can act as potent algicides against harmful algal blooms.
KW - Algicides
KW - Harmful algal blooms
KW - Red tide
KW - Thiazolidinediones
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=78149466282&partnerID=8YFLogxK
U2 - 10.1007/s12010-010-9001-5
DO - 10.1007/s12010-010-9001-5
M3 - Article
C2 - 20544303
AN - SCOPUS:78149466282
SN - 0273-2289
VL - 162
SP - 2273
EP - 2283
JO - Applied Biochemistry and Biotechnology
JF - Applied Biochemistry and Biotechnology
IS - 8
ER -