TY - JOUR
T1 - Three-dimensional configuration of subretinal fluid in central serous chorioretinopathy
AU - Ahn, Soh Eun
AU - Oh, Jaeryung
AU - Oh, Jong Hyun
AU - Oh, In Kyung
AU - Kim, Seong Woo
AU - Huh, Kuhl
PY - 2013
Y1 - 2013
N2 - PURPOSE. The purpose of this study was to characterize the 3-dimensional (3D) configuration of subretinal fluid (SRF) in idiopathic central serous chorioretinopathy (CSC) using spectral-domain optical coherence tomography (SDOCT). METHODS. The OCT images of patients with CSC were reviewed retrospectively. The 3D configurations of SRF were assessed using a modified segmentation algorithm of SDOCT. The differences of the configurations between acute and chronic CSC were compared. For the patients with acute CSC, we investigated a possible relationship between early change in 3D configuration and disease prognosis. RESULTS. We included 69 eyes of 68 patients in this study. The mean volume, the greatest basal diameter (GBD), and the area of SRF were not different between acute and chronic CSC. The mean peak height (PH) of SRF and the ratio of PH to GBD in acute CSC (298.13 ± 92.67 lm, 9.44 ± 2.57%) were significantly greater than those in chronic CSC (192.97 ± 71.05 lm, 5.97 ± 1.90%; P < 0.001, P < 0.001, respectively). In patients with acute CSC, the early changing pattern of 3D configurations was significantly different according to the SRF prognosis (P = 0.003). In situ decrease of SRF was observed in 94.7% of the spontaneously resolving group. However, downward elongation of SRF was observed more frequently in the persistent group (58.3%) than in the spontaneously resolving group (6.3%). CONCLUSIONS. The 3D configurations of SRF were different between acute and chronic CSC. In patients with acute onset, the early change of 3D configuration was different and varied according to the SRF prognosis.
AB - PURPOSE. The purpose of this study was to characterize the 3-dimensional (3D) configuration of subretinal fluid (SRF) in idiopathic central serous chorioretinopathy (CSC) using spectral-domain optical coherence tomography (SDOCT). METHODS. The OCT images of patients with CSC were reviewed retrospectively. The 3D configurations of SRF were assessed using a modified segmentation algorithm of SDOCT. The differences of the configurations between acute and chronic CSC were compared. For the patients with acute CSC, we investigated a possible relationship between early change in 3D configuration and disease prognosis. RESULTS. We included 69 eyes of 68 patients in this study. The mean volume, the greatest basal diameter (GBD), and the area of SRF were not different between acute and chronic CSC. The mean peak height (PH) of SRF and the ratio of PH to GBD in acute CSC (298.13 ± 92.67 lm, 9.44 ± 2.57%) were significantly greater than those in chronic CSC (192.97 ± 71.05 lm, 5.97 ± 1.90%; P < 0.001, P < 0.001, respectively). In patients with acute CSC, the early changing pattern of 3D configurations was significantly different according to the SRF prognosis (P = 0.003). In situ decrease of SRF was observed in 94.7% of the spontaneously resolving group. However, downward elongation of SRF was observed more frequently in the persistent group (58.3%) than in the spontaneously resolving group (6.3%). CONCLUSIONS. The 3D configurations of SRF were different between acute and chronic CSC. In patients with acute onset, the early change of 3D configuration was different and varied according to the SRF prognosis.
KW - Central serous chorioretinopathy
KW - Optical coherence tomography
KW - Subretinal fluid
KW - Three-dimensional configuration
UR - http://www.scopus.com/inward/record.url?scp=84884243069&partnerID=8YFLogxK
U2 - 10.1167/iovs.13-12279
DO - 10.1167/iovs.13-12279
M3 - Article
C2 - 23920371
AN - SCOPUS:84884243069
SN - 0146-0404
VL - 54
SP - 5944
EP - 5952
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 9
ER -