Time-Dependent Controlled Release of Ferulic Acid from Surface-Modified Hollow Nanoporous Silica Particles

Tetsuo Yamaguchi, Taeho Kim, Jin Kuen Park, Jae Min Oh

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Release of ferulic acid from surface-functionalized hollow nanoporous silica particles (HNSPs) was investigated in deionized water (DI water) and in ethanol. The host material, an HNSP, was synthesized in the presence of polymer and surfactant templates, and the pore as well as the surface were modified with either pentyltriethoxysilane (PTS) or octyltriethoxysilane (OTS) through silane coupling reactions. The inner hollow space occupied a volume of ~45% of the whole HNSP with a 2.54 nm pore channel in the wall. The pore size was estimated to decrease to 1.5 nm and 0.5 nm via the PTS and OTS functionalization, respectively. The encapsulation efficiencies of the HNSP (25 wt%), PTS-functionalized HNSP (PTS-HNSP, 22 wt%) and OTS-functionalized HNSP (OST-HNSP, 25 wt%) toward ferulic acid were similar, while the %release in DI water and ethanol varied following HNSP > PTS-HNSP > OTS-HNSP. Release kinetic analyses with Korsmeyer–Peppas fitting suggested a trade-off relationship between the solvent’s ability to access the HNSP and the affinity of ferulic acid to the surface, allowing us to understand the solvent’s controlled release rate and mechanism.

Original languageEnglish
Article number10560
JournalInternational Journal of Molecular Sciences
Volume24
Issue number13
DOIs
StatePublished - Jul 2023

Keywords

  • drug delivery
  • hollow silica particle
  • mesoporous silica
  • surface functionalization

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