TY - JOUR
T1 - Toxicity of zinc oxide nanoparticles in rats treated by two different routes
T2 - Single intravenous injection and single oral administration
AU - Choi, Jonghye
AU - Kim, Heyjin
AU - Kim, Pilje
AU - Jo, Eunhye
AU - Kim, Hyun Mi
AU - Lee, Moo Yeol
AU - Jin, Seon Mi
AU - Park, Kwangsik
N1 - Publisher Copyright:
© 2014 Taylor & Francis Group, LLC.
PY - 2015/2/16
Y1 - 2015/2/16
N2 - Toxicokinetics of zinc oxide nanoparticles (ZnONP) was studied in rats via a single intravenous (iv) injection and a single oral administration (3 mg/kg or 30 mg/kg), respectively. Blood concentrations of zinc (Zn) were monitored for 7 d and tissue distribution were determined in liver, kidneys, lung, spleen, thymus, brain, and testes. To ascertain the excretion of ZnONP, Zn levels in urine and feces were measured for 7 d. ZnONP were not readily absorbed from the gastrointestinal tract (GIT) after oral administration and were excreted mostly in feces. When the nanoparticles were injected iv to rats at a dose of 30 mg/kg, peak concentration appeared at 5 min but returned to normal range by d 2 (48 h after injection). ZnONP were distributed mainly to liver, kidneys, lung, and spleen, but not to thymus, brain, and testes. The distribution level was significantly decreased to normal by d 7. Feces excretion levels after iv injection supported biliary excretion of ZnONP. In rats injected iv with 30 mg/kg, mitotic figures in hepatocytes were significantly increased and multifocal acute injuries with dark brown pigment were noted in lungs, while no significant damage was observed in rats treated orally with the same dosage. Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/uteh
AB - Toxicokinetics of zinc oxide nanoparticles (ZnONP) was studied in rats via a single intravenous (iv) injection and a single oral administration (3 mg/kg or 30 mg/kg), respectively. Blood concentrations of zinc (Zn) were monitored for 7 d and tissue distribution were determined in liver, kidneys, lung, spleen, thymus, brain, and testes. To ascertain the excretion of ZnONP, Zn levels in urine and feces were measured for 7 d. ZnONP were not readily absorbed from the gastrointestinal tract (GIT) after oral administration and were excreted mostly in feces. When the nanoparticles were injected iv to rats at a dose of 30 mg/kg, peak concentration appeared at 5 min but returned to normal range by d 2 (48 h after injection). ZnONP were distributed mainly to liver, kidneys, lung, and spleen, but not to thymus, brain, and testes. The distribution level was significantly decreased to normal by d 7. Feces excretion levels after iv injection supported biliary excretion of ZnONP. In rats injected iv with 30 mg/kg, mitotic figures in hepatocytes were significantly increased and multifocal acute injuries with dark brown pigment were noted in lungs, while no significant damage was observed in rats treated orally with the same dosage. Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/uteh
UR - http://www.scopus.com/inward/record.url?scp=84923355152&partnerID=8YFLogxK
U2 - 10.1080/15287394.2014.949949
DO - 10.1080/15287394.2014.949949
M3 - Article
C2 - 25674826
AN - SCOPUS:84923355152
SN - 1528-7394
VL - 78
SP - 226
EP - 243
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 4
ER -