Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex

Gu Kang Ung; Je Jeon Won; Yeni Kim; Kee Chung Chun; Bae Park Joo; Sung Juhnn Yong; Yong Sik Kim

doi:10.1016/j.neulet.2005.08.020

Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex

Gu Kang Ung, Je Jeon Won, Yeni Kim, Kee Chung Chun, Bae Park Joo, Sung Juhnn Yong, Yong Sik Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3β (GSK-3β), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins.

Original language	English
Pages (from-to)	171-175
Number of pages	5
Journal	Neuroscience Letters
Volume	390
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2005.08.020
State	Published - 30 Dec 2005

Keywords

Electroconvulsive shock
Frontal cortex
Phosphorylation
Protein kinase
Protein phosphatase 2A
Rat brain

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10.1016/j.neulet.2005.08.020

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title = "Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex",

abstract = "We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3β (GSK-3β), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins.",

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AU - Ung, Gu Kang

AU - Won, Je Jeon

AU - Kim, Yeni

AU - Chun, Kee Chung

AU - Joo, Bae Park

AU - Yong, Sung Juhnn

AU - Kim, Yong Sik

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AB - We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3β (GSK-3β), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins.

KW - Electroconvulsive shock

KW - Frontal cortex

KW - Phosphorylation

KW - Protein kinase

KW - Protein phosphatase 2A

KW - Rat brain

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Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex

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Keywords

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