Tumour regression via integrative regulation of neurological, inflammatory, and hypoxic tumour microenvironment

Chang Hoon Lee, Jungsook Cho, Kyeong Lee

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Changing trends in anticancer research have altered the treatment paradigm to the extent that it is difficult to investigate any anticancer drugs without mentioning immunotherapy. Thus, we are finally contemplating tumour regression using magic bullets known as immunotherapy drugs. This review explores the possible options and pitfalls in tumour regression by first elucidating the features of cancer and the importance of tumour microenvironments. Next, we evaluated the trends of anticancer therapeutics regulating tumour microenvironment. Finally, we introduced the concept of tumour regression and various targets of tumour microenvironment, which can be used in combination with current immunotherapy for tumour regression. In particular, we emphasize the importance of regulating the neurological manifestations of tumour microenvironment (N) in addition to inflammation (I) and hypoxia (H) in cancer.

Original languageEnglish
Pages (from-to)119-130
Number of pages12
JournalBiomolecules and Therapeutics
Volume28
Issue number2
DOIs
StatePublished - 2020

Keywords

  • Hypoxia
  • Immunotherapy
  • Inflammation
  • Neurological
  • Tumour microenvironment
  • Tumour regression

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