Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui

Young Mi Kim; Jongmin Ahn; Hee Sung Chae; Young Hee Choi; Jinwoong Kim; Young Won Chin

doi:10.1016/j.bmcl.2018.02.050

Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui

Young Mi Kim, Jongmin Ahn, Hee Sung Chae, Young Hee Choi, Jinwoong Kim, Young Won Chin

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

As part of our ongoing search for anti-inflammatory compounds from higher plants, we isolated and elucidated two new diterpenoid glycosides, kansuingol A (1) and kansuingol B (2), from the roots of Euphorbia kansui. These structures were elucidated by extensive spectroscopic methods such as NMR and MS. Compounds were assessed for their IL-6 production inhibitory activity in PMA + A23187-stimulated HMC-1 cells. As a result, compounds 1 and 2 exerted inhibitory activities in the production of IL-6 with IC₅₀ values of 2.96, and 1.94 μM, respectively. Further, kansuingol A (1) decreased mRNA expressions of TNF-α and IL-6.

Original language	English
Pages (from-to)	1207-1210
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	28
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2018.02.050
State	Published - 15 Apr 2018

Keywords

Anti-inflammatory
Diterpenoid
Euphorbia kansui
IL-6
Kansuingol A
Kansuingol B
TNF-α

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title = "Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui",

abstract = "As part of our ongoing search for anti-inflammatory compounds from higher plants, we isolated and elucidated two new diterpenoid glycosides, kansuingol A (1) and kansuingol B (2), from the roots of Euphorbia kansui. These structures were elucidated by extensive spectroscopic methods such as NMR and MS. Compounds were assessed for their IL-6 production inhibitory activity in PMA + A23187-stimulated HMC-1 cells. As a result, compounds 1 and 2 exerted inhibitory activities in the production of IL-6 with IC50 values of 2.96, and 1.94 μM, respectively. Further, kansuingol A (1) decreased mRNA expressions of TNF-α and IL-6.",

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author = "Kim, {Young Mi} and Jongmin Ahn and Chae, {Hee Sung} and Choi, {Young Hee} and Jinwoong Kim and Chin, {Young Won}",

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T1 - Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui

AU - Kim, Young Mi

AU - Ahn, Jongmin

AU - Chae, Hee Sung

AU - Choi, Young Hee

AU - Kim, Jinwoong

AU - Chin, Young Won

PY - 2018/4/15

Y1 - 2018/4/15

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AB - As part of our ongoing search for anti-inflammatory compounds from higher plants, we isolated and elucidated two new diterpenoid glycosides, kansuingol A (1) and kansuingol B (2), from the roots of Euphorbia kansui. These structures were elucidated by extensive spectroscopic methods such as NMR and MS. Compounds were assessed for their IL-6 production inhibitory activity in PMA + A23187-stimulated HMC-1 cells. As a result, compounds 1 and 2 exerted inhibitory activities in the production of IL-6 with IC50 values of 2.96, and 1.94 μM, respectively. Further, kansuingol A (1) decreased mRNA expressions of TNF-α and IL-6.

KW - Anti-inflammatory

KW - Diterpenoid

KW - Euphorbia kansui

KW - IL-6

KW - Kansuingol A

KW - Kansuingol B

KW - TNF-α

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Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui

Abstract

Keywords

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